TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease.

Zhang, Youwen; Feng, Shujun; Nie, Kun; Li, Yan; Gao, Yuyuan; Gan, Rong; Wang, Limin; Li, Bing; Sun, Xuegang; Wang, Lijuan; Zhang, Yuhu

Zhang, Youwen; Feng, Shujun; Nie, Kun; Li, Yan; Gao, Yuyuan; Gan, Rong; Wang, Limin; Li, Bing; Sun, Xuegang; Wang, Lijuan; Zhang, Yuhu.

Afiliação

Zhang Y; Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China; Department of Neurology, The People's Hospital of Gaozhou, Guangdong, China.
Feng S; Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Nie K; Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Li Y; Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Gao Y; Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Gan R; Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Wang L; Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Li B; Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Sun X; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Wang L; Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. Electronic address: wljgd68@163.com.
Zhang Y; Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. Electronic address: yhzhangsd@126.com.

Biochem Biophys Res Commun ; 499(4): 797-802, 2018 05 23.

Article em En | MEDLINE | ID: mdl-29621548

Assuntos

Inflamação/metabolismo; Inflamação/patologia; Glicoproteínas de Membrana/metabolismo; Microglia/metabolismo; Microglia/patologia; Doença de Parkinson/metabolismo; Doença de Parkinson/patologia; Receptores Imunológicos/metabolismo; 1-Metil-4-Fenil-1,2,3,6-Tetra-Hidropiridina; Animais; Arginase/metabolismo; Linhagem Celular; Polaridade Celular; Citocinas/genética; Citocinas/metabolismo; Modelos Animais de Doenças; Neurônios Dopaminérgicos/metabolismo; Neurônios Dopaminérgicos/patologia; Técnicas de Silenciamento de Genes; Lentivirus/metabolismo; Masculino; Camundongos Endogâmicos C57BL; Doença de Parkinson/genética; Fenótipo; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Transdução Genética; Regulação para Cima/genética

Palavras-chave

Microglia; Neuroinflammation; Parkinson's disease; Polarization; Triggering receptor expressed on myeloid cells 2

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Glicoproteínas de Membrana / Receptores Imunológicos / Microglia / Inflamação Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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