Flagellin-fused protein targeting M2e and HA2 induces potent humoral and T-cell responses and protects mice against various influenza viruses a subtypes.

Stepanova, Liudmila A; Mardanova, Eugenia S; Shuklina, Marina A; Blokhina, Elena A; Kotlyarov, Roman Y; Potapchuk, Marina V; Kovaleva, Anna A; Vidyaeva, Inna G; Korotkov, Alexandr V; Eletskaya, Elizaveta I; Ravin, Nikolai V; Tsybalova, Liudmila M

Stepanova, Liudmila A; Mardanova, Eugenia S; Shuklina, Marina A; Blokhina, Elena A; Kotlyarov, Roman Y; Potapchuk, Marina V; Kovaleva, Anna A; Vidyaeva, Inna G; Korotkov, Alexandr V; Eletskaya, Elizaveta I; Ravin, Nikolai V; Tsybalova, Liudmila M.

Afiliação

Stepanova LA; Research Institute of Influenza, Russian Ministry of Health, Prof. Popova str.15/17, 197376, St. Petersburg, Russia. stepanoval60@mail.ru.
Mardanova ES; Institute of Bioengineering, Research Center of Biotechnology, Russian Academy of Sciences, Leninsky Ave. 33, building 2, 119071, Moscow, Russia.
Shuklina MA; Research Institute of Influenza, Russian Ministry of Health, Prof. Popova str.15/17, 197376, St. Petersburg, Russia.
Blokhina EA; Institute of Bioengineering, Research Center of Biotechnology, Russian Academy of Sciences, Leninsky Ave. 33, building 2, 119071, Moscow, Russia.
Kotlyarov RY; Institute of Bioengineering, Research Center of Biotechnology, Russian Academy of Sciences, Leninsky Ave. 33, building 2, 119071, Moscow, Russia.
Potapchuk MV; Research Institute of Influenza, Russian Ministry of Health, Prof. Popova str.15/17, 197376, St. Petersburg, Russia.
Kovaleva AA; Research Institute of Influenza, Russian Ministry of Health, Prof. Popova str.15/17, 197376, St. Petersburg, Russia.
Vidyaeva IG; Research Institute of Influenza, Russian Ministry of Health, Prof. Popova str.15/17, 197376, St. Petersburg, Russia.
Korotkov AV; Research Institute of Influenza, Russian Ministry of Health, Prof. Popova str.15/17, 197376, St. Petersburg, Russia.
Eletskaya EI; Research Institute of Influenza, Russian Ministry of Health, Prof. Popova str.15/17, 197376, St. Petersburg, Russia.
Ravin NV; Institute of Bioengineering, Research Center of Biotechnology, Russian Academy of Sciences, Leninsky Ave. 33, building 2, 119071, Moscow, Russia.
Tsybalova LM; Research Institute of Influenza, Russian Ministry of Health, Prof. Popova str.15/17, 197376, St. Petersburg, Russia.

J Biomed Sci ; 25(1): 33, 2018 Apr 09.

Article em En | MEDLINE | ID: mdl-29631629

Assuntos

Epitopos/imunologia; Flagelina/imunologia; Imunogenicidade da Vacina/imunologia; Vírus da Influenza A/imunologia; Proteínas Recombinantes de Fusão/imunologia; Animais; Epitopos/genética; Feminino; Flagelina/genética; Camundongos; Camundongos Endogâmicos BALB C; Transporte Proteico; Proteínas Recombinantes de Fusão/genética; Vacinas de Subunidades Antigênicas/administração & dosagem; Vacinas de Subunidades Antigênicas/genética; Vacinas de Subunidades Antigênicas/imunologia; Vacinas Sintéticas/administração & dosagem; Vacinas Sintéticas/genética; Vacinas Sintéticas/imunologia; Proteínas da Matriz Viral/genética; Proteínas da Matriz Viral/metabolismo

Palavras-chave

Flagellin; HA2; Influenza virus; M2e ectodomain; Recombinant protein; Universal vaccine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Proteínas Recombinantes de Fusão / Flagelina / Imunogenicidade da Vacina / Epitopos Limite: Animals Idioma: En Revista: J Biomed Sci Assunto da revista: MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Federação Russa

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