A new flavonoid from Stellera chamaejasme L., stechamone, alleviated 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in a murine model.

Jo, Beom-Geun; Park, No-June; Jegal, Jonghwan; Choi, Sangho; Lee, Sang Woo; Jin, Hang; Kim, Su-Nam; Yang, Min Hye

Jo, Beom-Geun; Park, No-June; Jegal, Jonghwan; Choi, Sangho; Lee, Sang Woo; Jin, Hang; Kim, Su-Nam; Yang, Min Hye.

Afiliação

Jo BG; College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea.
Park NJ; Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung 25451, Republic of Korea.
Jegal J; College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea.
Choi S; International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
Lee SW; International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
Jin H; Institute of Medicinal Plants, Yunnan Academy of Agricultural Sciences, Yunnan 650205, China.
Kim SN; Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung 25451, Republic of Korea. Electronic address: snkim@kist.re.kr.
Yang MH; College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea. Electronic address: mhyang@pusan.ac.kr.

Int Immunopharmacol ; 59: 113-119, 2018 Jun.

Article em En | MEDLINE | ID: mdl-29653408

Assuntos

Antialérgicos/uso terapêutico; Dermatite Atópica/tratamento farmacológico; Flavonoides/uso terapêutico; Thymelaeaceae; Animais; Antialérgicos/farmacologia; Linhagem Celular; Dermatite Atópica/sangue; Dermatite Atópica/induzido quimicamente; Dinitroclorobenzeno; Modelos Animais de Doenças; Feminino; Flavonoides/farmacologia; Imunoglobulina E/sangue; Interleucina-4/sangue; Interleucina-4/genética; Camundongos Pelados; Ratos; Pele/efeitos dos fármacos; Pele/metabolismo; Pele/patologia

Palavras-chave

2,4-Dinitrochlorobenzene; Atopic dermatitis; Interleukin 4; Skin barrier function; Stechamone; Stellera chamaejasme L.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Flavonoides / Antialérgicos / Thymelaeaceae / Dermatite Atópica Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Int Immunopharmacol Assunto da revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article

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