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Fungi short-chain carboxylate transporter: shift from microbe hereditary functional component to metabolic engineering target.
Guo, Hongwei; Huang, Tianqiu; Zhao, Jun; Chen, Hongwen; Chen, Guo.
Afiliação
  • Guo H; Department of Biotechnology and Bioengineering, School of Chemical Engineering and Key Laboratory of Fujian Province for Biochemical Technology, National Huaqiao University, 668 Jimei Road, Amoy, 361021, Fujian, China. guohw@hqu.edu.cn.
  • Huang T; Department of Biotechnology and Bioengineering, School of Chemical Engineering and Key Laboratory of Fujian Province for Biochemical Technology, National Huaqiao University, 668 Jimei Road, Amoy, 361021, Fujian, China.
  • Zhao J; Department of Biotechnology and Bioengineering, School of Chemical Engineering and Key Laboratory of Fujian Province for Biochemical Technology, National Huaqiao University, 668 Jimei Road, Amoy, 361021, Fujian, China.
  • Chen H; Department of Biotechnology and Bioengineering, School of Chemical Engineering and Key Laboratory of Fujian Province for Biochemical Technology, National Huaqiao University, 668 Jimei Road, Amoy, 361021, Fujian, China.
  • Chen G; Department of Biotechnology and Bioengineering, School of Chemical Engineering and Key Laboratory of Fujian Province for Biochemical Technology, National Huaqiao University, 668 Jimei Road, Amoy, 361021, Fujian, China.
Appl Microbiol Biotechnol ; 102(11): 4653-4662, 2018 Jun.
Article em En | MEDLINE | ID: mdl-29679102
Short-chain carboxylic acids and their derivatives are widely utilized in all aspects of our daily life. Given their specific functional groups, these molecules are also utilized in fine chemical synthesis. The traditional petroleum-based carboxylate production methods are restricted by petrol shortage and environmental pollution. Renowned for their more sustainable processes than traditional methods, biotechnological methods are preferred alternatives and have attracted increasing attention. However, the industrial application of biotechnological methods is currently limited by low factors: low productivity and low yield. Therefore, understanding the regulation of carboxylate accumulation will greatly enhance the industrial biotechnological production of short-chain carboxylate acids. The carboxylate transporter plays a crucial role in transmembrane uptake and secretion of carboxylate; therefore, regulating these transporters is of high academic and application relevance. This review concentrates on the physiological roles, regulation mechanisms, and harnessing strategies of Jen and AcpA orthologs in fungi, which provide potential clues for the biotechnological production of short-chain carboxylic acids with high efficiency.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Ácidos Carboxílicos / Engenharia Metabólica Idioma: En Revista: Appl Microbiol Biotechnol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Ácidos Carboxílicos / Engenharia Metabólica Idioma: En Revista: Appl Microbiol Biotechnol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China