Epidermis and lymphocyte interactions during a tuberculin skin reaction. I. Increased ETAF/IL-1 like activity, expression of tissue antigens and mixed skin lymphocyte reactivity.
Arch Dermatol Res
; 280(2): 83-8, 1988.
Article
em En
| MEDLINE
| ID: mdl-2969219
ABSTRACT
Forty-one persons were tested for tuberculin skin reactivity. Epidermal cells (ECs) were isolated from the tuberculin reaction and from a contra lateral, non injected skin area. We found a significant increase of epidermal thymocyte activating factor (ETAF) in epidermis overlying a positive tuberculin reaction together with an increase of OKT6 and class II (HLA-DR) positive cells. Allogeneic lymphocytes proliferated significantly more when mixed with ECs from a positive tuberculin skin test. Injection of tuberculin per se or a negative reaction did not induce similar changes. The described model seems useful for functional studies of ECs and lymphocytes in patients with contact dermatitis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Teste Tuberculínico
/
Linfócitos T
/
Interleucina-1
/
Epiderme
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Arch Dermatol Res
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Dinamarca