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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.
Wray, Naomi R; Ripke, Stephan; Mattheisen, Manuel; Trzaskowski, Maciej; Byrne, Enda M; Abdellaoui, Abdel; Adams, Mark J; Agerbo, Esben; Air, Tracy M; Andlauer, Till M F; Bacanu, Silviu-Alin; Bækvad-Hansen, Marie; Beekman, Aartjan F T; Bigdeli, Tim B; Binder, Elisabeth B; Blackwood, Douglas R H; Bryois, Julien; Buttenschøn, Henriette N; Bybjerg-Grauholm, Jonas; Cai, Na; Castelao, Enrique; Christensen, Jane Hvarregaard; Clarke, Toni-Kim; Coleman, Jonathan I R; Colodro-Conde, Lucía; Couvy-Duchesne, Baptiste; Craddock, Nick; Crawford, Gregory E; Crowley, Cheynna A; Dashti, Hassan S; Davies, Gail; Deary, Ian J; Degenhardt, Franziska; Derks, Eske M; Direk, Nese; Dolan, Conor V; Dunn, Erin C; Eley, Thalia C; Eriksson, Nicholas; Escott-Price, Valentina; Kiadeh, Farnush Hassan Farhadi; Finucane, Hilary K; Forstner, Andreas J; Frank, Josef; Gaspar, Héléna A; Gill, Michael; Giusti-Rodríguez, Paola; Goes, Fernando S; Gordon, Scott D; Grove, Jakob.
Afiliação
  • Wray NR; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. naomi.wray@uq.edu.au.
  • Ripke S; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. naomi.wray@uq.edu.au.
  • Mattheisen M; Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
  • Trzaskowski M; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
  • Byrne EM; Department of Psychiatry and Psychotherapy, Universitätsmedizin Berlin Campus Charité Mitte, Berlin, Germany.
  • Abdellaoui A; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
  • Adams MJ; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.
  • Agerbo E; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
  • Air TM; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
  • Andlauer TMF; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
  • Bacanu SA; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
  • Bækvad-Hansen M; Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Beekman AFT; Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
  • Bigdeli TB; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
  • Binder EB; Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark.
  • Blackwood DRH; National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
  • Bryois J; Discipline of Psychiatry, University of Adelaide, Adelaide, South Australia, Australia.
  • Buttenschøn HN; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
  • Bybjerg-Grauholm J; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
  • Cai N; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
  • Castelao E; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
  • Christensen JH; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
  • Clarke TK; Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands.
  • Coleman JIR; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
  • Colodro-Conde L; Virginia Institute for Psychiatric and Behavior Genetics, Richmond, VA, USA.
  • Couvy-Duchesne B; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
  • Craddock N; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
  • Crawford GE; Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
  • Crowley CA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Dashti HS; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.
  • Davies G; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
  • Deary IJ; Department of Clinical Medicine, Translational Neuropsychiatry Unit, Aarhus University, Aarhus, Denmark.
  • Degenhardt F; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
  • Derks EM; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
  • Direk N; Statistical Genomics and Systems Genetics, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK.
  • Dolan CV; Human Genetics, Wellcome Trust Sanger Institute, Cambridge, UK.
  • Dunn EC; Department of Psychiatry, University Hospital of Lausanne, Prilly, Switzerland.
  • Eley TC; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
  • Eriksson N; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.
  • Escott-Price V; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
  • Kiadeh FHF; Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
  • Finucane HK; MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
  • Forstner AJ; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
  • Frank J; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
  • Gaspar HA; Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia.
  • Gill M; Psychological Medicine, Cardiff University, Cardiff, UK.
  • Giusti-Rodríguez P; Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.
  • Goes FS; Department of Pediatrics, Division of Medical Genetics, Duke University, Durham, NC, USA.
  • Gordon SD; Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Grove J; Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Nat Genet ; 50(5): 668-681, 2018 05.
Article em En | MEDLINE | ID: mdl-29700475
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Herança Multifatorial / Transtorno Depressivo Maior Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Female / Humans / Male Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Austrália
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Herança Multifatorial / Transtorno Depressivo Maior Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Female / Humans / Male Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Austrália