Influence of composition of cysteine-containing peptide-based chelators on biodistribution of <sup>99m</sup>Tc-labeled anti-EGFR affibody molecules.

Oroujeni, Maryam; Andersson, Ken G; Steinhardt, Xenia; Altai, Mohamed; Orlova, Anna; Mitran, Bogdan; Vorobyeva, Anzhelika; Garousi, Javad; Tolmachev, Vladimir; Löfblom, John

Influence of composition of cysteine-containing peptide-based chelators on biodistribution of ^99mTc-labeled anti-EGFR affibody molecules.

Oroujeni, Maryam; Andersson, Ken G; Steinhardt, Xenia; Altai, Mohamed; Orlova, Anna; Mitran, Bogdan; Vorobyeva, Anzhelika; Garousi, Javad; Tolmachev, Vladimir; Löfblom, John.

Afiliação

Oroujeni M; Department of Immunology, Genetics and Pathology, Uppsala University, 75181, Uppsala, Sweden.
Andersson KG; Department of Immunology, Genetics and Pathology, Uppsala University, 75181, Uppsala, Sweden.
Steinhardt X; Department of Protein Science, KTH-Royal Institute of Technology, Stockholm, Sweden.
Altai M; Department of Immunology, Genetics and Pathology, Uppsala University, 75181, Uppsala, Sweden.
Orlova A; Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Mitran B; Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Vorobyeva A; Department of Immunology, Genetics and Pathology, Uppsala University, 75181, Uppsala, Sweden.
Garousi J; Department of Immunology, Genetics and Pathology, Uppsala University, 75181, Uppsala, Sweden.
Tolmachev V; Department of Immunology, Genetics and Pathology, Uppsala University, 75181, Uppsala, Sweden. vladimir.tolmachev@igp.uu.se.
Löfblom J; Department of Protein Science, KTH-Royal Institute of Technology, Stockholm, Sweden.

Amino Acids ; 50(8): 981-994, 2018 Aug.

Article em En | MEDLINE | ID: mdl-29728916

Assuntos

Imagem Molecular; Sondas Moleculares/química; Sondas Moleculares/farmacocinética; Animais; Linhagem Celular Tumoral; Quelantes; Cisteína; Receptores ErbB/análise; Receptores ErbB/biossíntese; Receptores ErbB/química; Humanos; Camundongos; Imagem Molecular/métodos; Transplante de Neoplasias; Neoplasias/metabolismo; Peptídeos; Proteínas Recombinantes de Fusão/análise; Proteínas Recombinantes de Fusão/química; Tecnécio; Distribuição Tecidual

Palavras-chave

99mTc; Affibody molecules; EGFR; Glutamate; Peptide-based chelators

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sondas Moleculares / Imagem Molecular Limite: Animals / Humans Idioma: En Revista: Amino Acids Assunto da revista: BIOQUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Suécia

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