Complementary middle-down and intact monoclonal antibody proteoform characterization by capillary zone electrophoresis - mass spectrometry.

Belov, Arseniy M; Zang, Li; Sebastiano, Roberto; Santos, Marcia R; Bush, David R; Karger, Barry L; Ivanov, Alexander R

Belov, Arseniy M; Zang, Li; Sebastiano, Roberto; Santos, Marcia R; Bush, David R; Karger, Barry L; Ivanov, Alexander R.

Afiliação

Belov AM; Department of Chemistry and Chemical Biology, Barnett Institute of Chemical and Biological Analysis, Northeastern University, Boston, MA, USA.
Zang L; Analytical Development Department, Biogen, Cambridge, MA, USA.
Sebastiano R; Department of Chemistry, Material and Chemical Engineering "Giulio Natta", Polytechnic of Milan, Milan, Italy.
Santos MR; SCIEX, Brea, CA, USA.
Bush DR; Genedata Inc, Lexington, MA, USA.
Karger BL; Department of Chemistry and Chemical Biology, Barnett Institute of Chemical and Biological Analysis, Northeastern University, Boston, MA, USA.
Ivanov AR; Department of Chemistry and Chemical Biology, Barnett Institute of Chemical and Biological Analysis, Northeastern University, Boston, MA, USA.

Electrophoresis ; 39(16): 2069-2082, 2018 08.

Article em En | MEDLINE | ID: mdl-29749064

Assuntos

Anticorpos Monoclonais/análise; Eletroforese Capilar/métodos; Glicosilação; Espectrometria de Massas

Palavras-chave

Capillary zone electrophoresis; Mass spectrometry; Middle-down proteomics; Monoclonal antibody; Native mass spectrometry

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Eletroforese Capilar / Anticorpos Monoclonais Idioma: En Revista: Electrophoresis Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

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