Inactivation of deubiquitinase CYLD enhances therapeutic antibody production in Chinese hamster ovary cells.

Lu, Yafang; Zhou, Qin; Han, Qianqian; Wu, Pengfei; Zhang, Lanlan; Zhu, Lin; Weaver, David T; Xu, Changzhi; Zhang, Buchang

Lu, Yafang; Zhou, Qin; Han, Qianqian; Wu, Pengfei; Zhang, Lanlan; Zhu, Lin; Weaver, David T; Xu, Changzhi; Zhang, Buchang.

Afiliação

Lu Y; Institute of Physical Science and Information Technology, Anhui University, Hefei, Anhui, 230601, People's Republic of China.
Zhou Q; Institute of Physical Science and Information Technology, Anhui University, Hefei, Anhui, 230601, People's Republic of China.
Han Q; Institute of Physical Science and Information Technology, Anhui University, Hefei, Anhui, 230601, People's Republic of China.
Wu P; Institute of Physical Science and Information Technology, Anhui University, Hefei, Anhui, 230601, People's Republic of China.
Zhang L; Institute of Physical Science and Information Technology, Anhui University, Hefei, Anhui, 230601, People's Republic of China.
Zhu L; Institute of Physical Science and Information Technology, Anhui University, Hefei, Anhui, 230601, People's Republic of China.
Weaver DT; Institute of Physical Science and Information Technology, Anhui University, Hefei, Anhui, 230601, People's Republic of China.
Xu C; Institute of Physical Science and Information Technology, Anhui University, Hefei, Anhui, 230601, People's Republic of China. changzhixu007@163.com.
Zhang B; Institute of Physical Science and Information Technology, Anhui University, Hefei, Anhui, 230601, People's Republic of China. zhbc@ahu.edu.cn.

Appl Microbiol Biotechnol ; 102(14): 6081-6093, 2018 Jul.

Article em En | MEDLINE | ID: mdl-29766242

Assuntos

Apoptose/genética; Engenharia Celular; Proliferação de Células/genética; Enzima Desubiquitinante CYLD/genética; Inativação Gênica; Imunoglobulina G/biossíntese; Animais; Anticorpos Biespecíficos/biossíntese; Células CHO; Sistemas CRISPR-Cas; Cricetinae; Cricetulus; Deleção de Genes; Genes Supressores de Tumor; Humanos; Rituximab/biossíntese; Trastuzumab/biossíntese

Palavras-chave

CHO cells; CRISPR-Cas9; CYLD; Cell engineering; Therapeutic antibody

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina G / Apoptose / Inativação Gênica / Proliferação de Células / Engenharia Celular / Enzima Desubiquitinante CYLD Limite: Animals / Humans Idioma: En Revista: Appl Microbiol Biotechnol Ano de publicação: 2018 Tipo de documento: Article

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