The roles of CyPA and CD147 in cardiac remodelling.
Exp Mol Pathol
; 104(3): 222-226, 2018 06.
Article
em En
| MEDLINE
| ID: mdl-29772453
ABSTRACT
Cyclophilin A (CyPA), an abundantly expressed protein belonging to the immunophilin family, is involved in a variety of physiological and pathological activities together with its extracellular receptor, CD147. Many studies have provided compelling evidence supporting critical roles of CyPA in immune and infectious diseases and malignant tumours. Recent studies have revealed that both CyPA and CD147 strongly promote cardiovascular inflammation, myocardial ischaemia-reperfusion injury, and myocardial remodelling processes. Here, we review the potential roles of CyPA and CD147 in cardiac remodelling and their implications for the development of novel pharmacological therapies for heart failure.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Ciclofilina A
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Basigina
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Remodelação Vascular
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Inflamação
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Exp Mol Pathol
Ano de publicação:
2018
Tipo de documento:
Article