Newborn adipokines and early childhood growth.
Pediatr Obes
; 13(8): 505-513, 2018 08.
Article
em En
| MEDLINE
| ID: mdl-29781193
ABSTRACT
BACKGROUND:
While adipokines can regulate satiety and energy metabolism, whether they are associated with childhood growth is unclear.OBJECTIVE:
To evaluate whether adipokine levels at birth are associated with growth.METHODS:
A total of 2264 singletons and 1144 twins from Upstate KIDS (born 2008-2010) had adiponectin, leptin, resistin and complement factor D measured in newborn blood spots. Parents reported anthropometry from paediatric visits via questionnaires every 4-6 months. Generalized linear mixed effects models were used to estimate growth trajectories through 3 years of age.RESULTS:
Among singletons, resistin and leptin were associated with greater weight-for-age (0.12 z-score units (95%CI 0.04, 0.20) [p = 0.003] and 0.15 (0.06, 0.24) [p = 0.001], respectively) and BMI z-score (0.11; 0.02, 0.20 [p = 0.02] and 0.18; 0.07, 0.28 [p = 0.002], respectively). After adjusting for birthweight, resistin and a ratio of resistin-to-adiponectin remained associated with weight through 3 years of age and odds of being overweight at 3 years of age in a subgroup of singletons. Among twins, adiponectin was associated with increased weight-for-age and length-for-age z-scores even after adjusting for birthweight (0.18; 0.08, 0.28 [p = 0.0006]; 0.20; 0.07, 0.33 [p = 0.003], respectively).CONCLUSIONS:
Levels of adipokines were associated with early childhood growth in small magnitudes. Resistin may be relevant for further examination in paediatric obesity.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peso Corporal
/
Aumento de Peso
/
Adipocinas
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Newborn
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Pediatr Obes
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos