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Developmental origins of pregnancy-induced cardiac changes: establishment of a novel model using the atrial natriuretic peptide gene-disrupted mice.
Ventura, Nicole M; Li, Terry Y; Tse, M Yat; Richard, Logan; Tayade, Chandrakant; Jin, Albert Y; Andrew, R David; Pang, Stephen C.
Afiliação
  • Ventura NM; Department of Biomedical and Molecular Sciences, Queen's University, Botterell Hall - 18 Stuart St., Kingston, ON, K7L 3N6, Canada.
  • Li TY; Department of Anatomy and Cell Biology, Faculty of Medicine, McGill University, Room 1/54 Strathcona Anatomy Building, 3640 University St., Montreal, QC, H3A 0C7, Canada.
  • Tse MY; Department of Biomedical and Molecular Sciences, Queen's University, Botterell Hall - 18 Stuart St., Kingston, ON, K7L 3N6, Canada.
  • Richard L; Department of Biomedical and Molecular Sciences, Queen's University, Botterell Hall - 18 Stuart St., Kingston, ON, K7L 3N6, Canada.
  • Tayade C; Department of Biomedical and Molecular Sciences, Queen's University, Botterell Hall - 18 Stuart St., Kingston, ON, K7L 3N6, Canada.
  • Jin AY; Department of Biomedical and Molecular Sciences, Queen's University, Botterell Hall - 18 Stuart St., Kingston, ON, K7L 3N6, Canada.
  • Andrew RD; Department of Biomedical and Molecular Sciences, Queen's University, Botterell Hall - 18 Stuart St., Kingston, ON, K7L 3N6, Canada.
  • Pang SC; Department of Medicine (Neurology), Kingston General Hospital, 76 Stuart St. Kingston, Kingston, ON, K7L 2V7, Canada.
Mol Cell Biochem ; 449(1-2): 227-236, 2018 Dec.
Article em En | MEDLINE | ID: mdl-29802597
Pregnancy evokes many challenges on the maternal cardiovascular system that may unmask predispositions for future disease. This is particularly evident for women who develop pregnancy-related disorders, for example, pre-eclampsia and gestational diabetes or hypertension. Such pregnancy-related syndromes increase the risk for cardiovascular disease (CVD) postpartum. As a result, pregnancy has been termed as a cardiovascular stress test and an indicator or marker to predict the development of CVD later in life. In addition, pregnancy-related disorders impact the development of offspring also placing them at a higher risk for disease. Utilizing pregnancy as a physiological stressor, the current investigation sought to determine whether the cardiovascular system of offspring exposed to gestational hypertension in utero would respond adversely to the stress of pregnancy. Heterozygous atrial natriuretic peptide gene-disrupted (ANP+/-) offspring were generated by either crossing male wildtype ANP+/+ with female knockout ANP-/- to produce ANP+/-KO mice or crossing female wildtype ANP+/+ with male knockout ANP-/- to produce ANP+/-WT mice. To study the cardiovascular stress induced by pregnancy, female ANP+/-WT and ANP+/-KO mice were mated with male wildtype ANP+/+ mice to initiate pregnancy. Cardiac size and molecular expression of the renin-angiotensin (RAS) and natriuretic peptide systems (NPS) were compared between offspring groups. Our data demonstrate that gestational hypertension and lack of maternal ANP did not significantly impact the progression and regression of pregnancy-induced cardiac hypertrophy over gestation and postpartum in ANP+/- offspring. Additionally, the molecular cardiac expression of the RAS and NPS did not differ between offspring groups. Future investigation should assess potential differences in cardiac function and the impact of fetal-programming on offspring cardiovascular adaptations during pregnancy in more severe models of pregnancy-related hypertensive syndrome such as angiotensin II or isoproterenol infusion.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Cardiovasculares na Gravidez / Fator Natriurético Atrial / Cardiomegalia Tipo de estudo: Prognostic_studies Limite: Animals / Pregnancy Idioma: En Revista: Mol Cell Biochem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Canadá

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Cardiovasculares na Gravidez / Fator Natriurético Atrial / Cardiomegalia Tipo de estudo: Prognostic_studies Limite: Animals / Pregnancy Idioma: En Revista: Mol Cell Biochem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Canadá