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Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.
Kim, Miriam Y; Yu, Kyung-Rok; Kenderian, Saad S; Ruella, Marco; Chen, Shirley; Shin, Tae-Hoon; Aljanahi, Aisha A; Schreeder, Daniel; Klichinsky, Michael; Shestova, Olga; Kozlowski, Miroslaw S; Cummins, Katherine D; Shan, Xinhe; Shestov, Maksim; Bagg, Adam; Morrissette, Jennifer J D; Sekhri, Palak; Lazzarotto, Cicera R; Calvo, Katherine R; Kuhns, Douglas B; Donahue, Robert E; Behbehani, Gregory K; Tsai, Shengdar Q; Dunbar, Cynthia E; Gill, Saar.
Afiliação
  • Kim MY; Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  • Yu KR; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Kenderian SS; Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA.
  • Ruella M; Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  • Chen S; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Shin TH; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Aljanahi AA; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA; Department of Chemistry and Molecular & Cellular Biology, Georgetown University, Washington, D.C. 20057, USA.
  • Schreeder D; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  • Klichinsky M; Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  • Shestova O; Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  • Kozlowski MS; Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  • Cummins KD; Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  • Shan X; Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  • Shestov M; Genomics and Computational Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Bagg A; Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  • Morrissette JJD; Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  • Sekhri P; The Ohio State University Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.
  • Lazzarotto CR; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Calvo KR; Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
  • Kuhns DB; Clinical Services Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.
  • Donahue RE; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Behbehani GK; The Ohio State University Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA; Division of Hematology, Department of Medicine, Ohio State University, Columbus, OH 43210, USA.
  • Tsai SQ; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Dunbar CE; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: dunbarc@nhlbi.nih.gov.
  • Gill S; Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. Electronic address: saargill@pennmedicine.upenn.edu.
Cell ; 173(6): 1439-1453.e19, 2018 05 31.
Article em En | MEDLINE | ID: mdl-29856956
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Hematopoéticas / Linfócitos T / Leucemia Mieloide Aguda / RNA Guia de Cinetoplastídeos / Lectina 3 Semelhante a Ig de Ligação ao Ácido Siálico / Imunoterapia Limite: Animals / Female / Humans / Male Idioma: En Revista: Cell Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Hematopoéticas / Linfócitos T / Leucemia Mieloide Aguda / RNA Guia de Cinetoplastídeos / Lectina 3 Semelhante a Ig de Ligação ao Ácido Siálico / Imunoterapia Limite: Animals / Female / Humans / Male Idioma: En Revista: Cell Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos