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Insulin-like growth factor 1 receptor stabilizes the ETV6-NTRK3 chimeric oncoprotein by blocking its KPC1/Rnf123-mediated proteasomal degradation.
Tognon, Cristina E; Rafn, Bo; Cetinbas, Naniye Malli; Kamura, Takumi; Trigo, Genny; Rotblat, Barak; Okumura, Fumihiko; Matsumoto, Masaki; Chow, Christine; Davare, Monika; Pollak, Michael; Mayor, Thibault; Sorensen, Poul H.
Afiliação
  • Tognon CE; From the Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada.
  • Rafn B; From the Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada.
  • Cetinbas NM; From the Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada.
  • Kamura T; the Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan, 812-8582.
  • Trigo G; From the Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada.
  • Rotblat B; From the Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada.
  • Okumura F; the Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan, 812-8582.
  • Matsumoto M; the Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan, 812-8582.
  • Chow C; From the Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada.
  • Davare M; the Department of Pediatrics, Oregon Health & Science University, Portland, Oregon 97239, and.
  • Pollak M; the Lady Davis Institute for Medical Research SMBD, Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada.
  • Mayor T; the Department of Biochemistry and Molecular Biology, Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
  • Sorensen PH; From the Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada, psor@mail.ubc.ca.
J Biol Chem ; 293(32): 12502-12515, 2018 08 10.
Article em En | MEDLINE | ID: mdl-29903916
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Fusão Oncogênica / Receptores de Somatomedina / Poliubiquitina / Ubiquitina-Proteína Ligases / Proteólise Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Canadá
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Fusão Oncogênica / Receptores de Somatomedina / Poliubiquitina / Ubiquitina-Proteína Ligases / Proteólise Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Canadá