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The long non-coding RNAs MHRT, FENDRR and CARMEN, their expression levels in peripheral blood mononuclear cells in patients with essential hypertension and their relation to heart hypertrophy.
Kontaraki, Joanna E; Marketou, Maria E; Kochiadakis, George E; Maragkoudakis, Spyros; Konstantinou, John; Vardas, Panos E; Parthenakis, Fragiskos I.
Afiliação
  • Kontaraki JE; Molecular Cardiology Laboratory, School of Medicine, University of Crete, Heraklion, Greece.
  • Marketou ME; Department of Cardiology, Heraklion University Hospital, Heraklion, Greece.
  • Kochiadakis GE; Department of Cardiology, Heraklion University Hospital, Heraklion, Greece.
  • Maragkoudakis S; Department of Cardiology, Heraklion University Hospital, Heraklion, Greece.
  • Konstantinou J; Department of Cardiology, Heraklion University Hospital, Heraklion, Greece.
  • Vardas PE; Department of Cardiology, Heraklion University Hospital, Heraklion, Greece.
  • Parthenakis FI; Department of Cardiology, Heraklion University Hospital, Heraklion, Greece.
Clin Exp Pharmacol Physiol ; 45(11): 1213-1217, 2018 11.
Article em En | MEDLINE | ID: mdl-29917257
Long non-coding RNAs (lncRNAs) participate in the modulation of cardiac hypertrophy, and they represent potential therapeutic targets in cardiovascular disease. We investigated the expression profiles of selected lncRNAs in peripheral blood mononuclear cells of patients with essential hypertension in relation to left ventricular hypertrophy. We assessed the expression levels of the lncRNAs MHRT, FENDRR and CARMEN using real-time reverse transcription polymerase chain reaction. Hypertensive patients showed significantly higher MHRT, FENDRR and CARMEN expression levels compared with healthy controls. In addition, we observed significant negative correlations of MHRT (r = -0.323, P = 0.003) and FENDRR (r = -0.380, P = 0.001) and a positive correlation of CARMEN (r = 0.458, P < 0.001) expression levels with left ventricular mass index. Our data reveal that the lncRNAs MHRT, FENDRR and CARMEN show distinct expression profiles in hypertensive patients and they possibly represent candidate therapeutic targets in hypertensive heart disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucócitos Mononucleares / Regulação da Expressão Gênica / Cardiomegalia / RNA Longo não Codificante / Hipertensão Essencial Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Exp Pharmacol Physiol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Grécia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucócitos Mononucleares / Regulação da Expressão Gênica / Cardiomegalia / RNA Longo não Codificante / Hipertensão Essencial Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Exp Pharmacol Physiol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Grécia