Neuroinformatics and Computational Modelling as Complementary Tools for Neurotoxicology Studies.
Basic Clin Pharmacol Toxicol
; 123 Suppl 5: 56-61, 2018 Sep.
Article
em En
| MEDLINE
| ID: mdl-29924904
ABSTRACT
Neuroinformatics is an area of science that aims to integrate neuroscience data and develop modern computational tools to increase our understanding of the functions of the nervous system in health and disease. Neuroinformatics tools include, among others, databases for storing and sharing data, repositories for managing documents and source code, and software tools for analysing, modelling and simulating signals and images. This MiniReview aims to present the state of the art in neuroinformatics and computational in silico modelling of neurobiological processes and neuroscientific phenomena as well as to discuss the use of in silico models in neurotoxicology research. In silico modelling can be considered a new, complementary tool in chemical design to predict potential neurotoxicity and in neurotoxicity testing to help clarify initial hypothesis obtained in in vitro and in vivo. Validated in silico models can be used to identify pharmacological targets, to help bridge in vitro and in vivo studies and, ultimately, to develop safer chemicals and efficient therapeutic strategies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Toxicologia
/
Neurociências
/
Biologia Computacional
/
Síndromes Neurotóxicas
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Basic Clin Pharmacol Toxicol
Assunto da revista:
FARMACOLOGIA
/
TOXICOLOGIA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Finlândia