Effects of chronic administration of amitriptyline or mianserin on rat cardiac and central adrenoceptors.
Br J Pharmacol
; 85(3): 635-8, 1985 Jul.
Article
em En
| MEDLINE
| ID: mdl-2992668
ABSTRACT
Rats were administered either amitriptyline (20 mg kg-1, i.p.) or mianserin (10 mg kg-1, i.p.) for 21 consecutive days and the alpha- and beta-adrenoceptor characteristics of cardiac ventricles, cerebral cortex and hippocampus examined by ligand-binding procedure. Chronic administration of amitriptyline significantly reduced the maximum density of beta-receptors in the cerebral cortex without significantly altering cardiac alpha- or beta-receptors; mianserin treatment had no significant effect on any of the receptors studied.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Receptores Adrenérgicos alfa
/
Receptores Adrenérgicos beta
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Dibenzazepinas
/
Coração
/
Amitriptilina
/
Mianserina
Limite:
Animals
Idioma:
En
Revista:
Br J Pharmacol
Ano de publicação:
1985
Tipo de documento:
Article