[Intervention effect of trillium tschonoskii maxim extract solution on myocardial injury in diabetic rats].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
; 32(2): 177-180, 2016 Feb 08.
Article
em Zh
| MEDLINE
| ID: mdl-29931872
ABSTRACT
OBJECTIVE:
To study the protective effect and the underlying mechanism of trillium tschonoskii maxim (TTM, Traditional Chinese Medicine) on myocardial injury of diabetic rats induced by high-fat diet and streptozotocin (STZ), which will lay a theoretical foundation for further exploring its pharmacological effect.METHODS:
SD male rats received high fat diet and STZ (35 mg/kg) via tail vein injection were modeled into diabetic rats, the levels of brain natriuretic peptide (BNP) and cardiac troponin I (cTnI) in serum, the contents of superoxide (SOD), glutathione peroxidase (GPX),malondialdehyde (MDA) in cardiac tissues, and cardiac myocyte apoptosis index were tested in all groups after the last administration.RESULTS:
Compared with that in the model group, SOD and GPX activities were significantly increased and levels of BNPãcTnIãcardiac weight index (CWI)ãapoptosis index (AI) were decreased in TTM and metformin (Met) group. The effects of TTM were better than traditional medicine metformin in enhancing GPX activity and decreasing collagen level.CONCLUSIONS:
TTM can inhibit myocardial apoptosis by reducing oxidative stress responses in diabetic rats, which can slow down collagen fiber production to protect the myocardial cell injury.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Trillium
/
Diabetes Mellitus Experimental
/
Coração
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Zhongguo Ying Yong Sheng Li Xue Za Zhi
Assunto da revista:
FISIOLOGIA
Ano de publicação:
2016
Tipo de documento:
Article