Establishment of a human medulloblastoma cell line and its heterotransplantation into nude mice.
J Neuropathol Exp Neurol
; 44(5): 472-85, 1985 Sep.
Article
em En
| MEDLINE
| ID: mdl-2993532
ABSTRACT
A permanent cell line arising from a cerebellar medulloblastoma was established and its growth characteristics were investigated. Although the original tumor inoculum failed to take, the cultured cells were readily tumorigenic in nude mice and gave rise to rapidly growing tumors which could be easily subpassaged. The primary tumor showed evidence of both glial and neuronal differentiation, and retention of neuronal differentiation, albeit minimal, occurred in both the cultured neoplastic cells and the nude mouse tumors. Glial differentiation, on the other hand, could not be demonstrated. G-banding analysis of the chromosomes present in the cell line showed that they were exclusively human.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cerebelares
/
Meduloblastoma
Limite:
Animals
/
Child, preschool
/
Humans
/
Male
Idioma:
En
Revista:
J Neuropathol Exp Neurol
Ano de publicação:
1985
Tipo de documento:
Article