A critically ill patient after a colchicine overdose below the lethal dose: a case report.
J Med Case Rep
; 12(1): 191, 2018 Jul 04.
Article
em En
| MEDLINE
| ID: mdl-29970148
ABSTRACT
BACKGROUND:
Although 0.8 mg/kg is considered a lethal dose of colchicine, fatal cases of patients who followed a critical disease course after an intake below this lethal dose have been reported. CASE PRESENTATION An 18-year-old Japanese woman who had taken an overdose of prescription colchicine (15 mg; 0.2 mg/kg) was brought to our emergency out-patient department. Although her colchicine intake was below 0.8 mg/kg (considered the lethal dose), she reached a critical state and underwent three phases characterizing colchicine poisoning (gastrointestinal symptoms, multiple organ failure, and recovery). Her condition was critical, with a Sequential Organ Failure Assessment score of a maximum of 14.CONCLUSIONS:
Patients might reach a critical stage after colchicine ingestion at a non-lethal dose. Thus, it might be necessary to review which dose of colchicine should be considered lethal.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor Abdominal
/
Colchicina
/
Moduladores de Tubulina
/
Overdose de Drogas
/
Insuficiência de Múltiplos Órgãos
Tipo de estudo:
Etiology_studies
Limite:
Adolescent
/
Animals
/
Female
/
Humans
Idioma:
En
Revista:
J Med Case Rep
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Japão