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Trousseau's syndrome triggered by an immune checkpoint blockade in a non-small cell lung cancer patient.
Horio, Yuko; Takamatsu, Koutaro; Tamanoi, Daisuke; Sato, Ryo; Saruwatari, Koichi; Ikeda, Tokunori; Nakane, Shunya; Nakajima, Makoto; Saeki, Sho; Ichiyasu, Hidenori; Fujii, Kazuhiko; Tomita, Yusuke.
Afiliação
  • Horio Y; Department of Respiratory Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
  • Takamatsu K; Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
  • Tamanoi D; Department of Respiratory Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
  • Sato R; Department of Respiratory Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
  • Saruwatari K; Department of Respiratory Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
  • Ikeda T; Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
  • Nakane S; Department of clinical investigation (biostatistics), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
  • Nakajima M; Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
  • Saeki S; Asian Neurological Intractable Diseases Research and Clinic (AIDReC), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
  • Ichiyasu H; Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
  • Fujii K; Department of Respiratory Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
  • Tomita Y; Department of Respiratory Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Eur J Immunol ; 48(10): 1764-1767, 2018 10.
Article em En | MEDLINE | ID: mdl-29981156
PD-1 blockade therapy activates T cells by blocking the interaction between PD-1 and PD-L1 and promotes IFN-γ and Th1 cytokine production. In turn, IFN-γ and Th1 cytokines produced by activated T cells promote TF synthesis in monocytes/macrophages, which results in hypercoagulability leading to thrombosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos da Coagulação Sanguínea / Carcinoma Pulmonar de Células não Pequenas / Anticorpos Monoclonais Humanizados Tipo de estudo: Diagnostic_studies / Etiology_studies Limite: Humans / Male / Middle aged Idioma: En Revista: Eur J Immunol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos da Coagulação Sanguínea / Carcinoma Pulmonar de Células não Pequenas / Anticorpos Monoclonais Humanizados Tipo de estudo: Diagnostic_studies / Etiology_studies Limite: Humans / Male / Middle aged Idioma: En Revista: Eur J Immunol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Japão