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Optical control of neuronal firing via photoinduced electron transfer in donor-acceptor conjugates.
Takano, Yuta; Numata, Tomohiro; Fujishima, Kazuto; Miyake, Kazuaki; Nakao, Kazuya; Grove, Wesley David; Inoue, Ryuji; Kengaku, Mineko; Sakaki, Shigeyoshi; Mori, Yasuo; Murakami, Tatsuya; Imahori, Hiroshi.
Afiliação
  • Takano Y; Institute for Integrated Cell-Material Sciences (WPI-iCeMS) , Kyoto University , Sakyo-ku , Kyoto 606-8501 , Japan . Email: kengaku@icems.kyoto-u.ac.jp.
  • Numata T; Department of Physiology , Graduate School of Medical Sciences , Fukuoka University , Nanakuma 7-45-1, Johnan-ku , Fukuoka 814-0180 , Japan.
  • Fujishima K; Department of Synthetic Chemistry and Biological Chemistry , Graduate School of Engineering , Kyoto University , Nishikyo-ku , Kyoto 615-8510 , Japan . Email: mori@sbchem.kyoto-u.ac.jp.
  • Miyake K; Institute for Integrated Cell-Material Sciences (WPI-iCeMS) , Kyoto University , Sakyo-ku , Kyoto 606-8501 , Japan . Email: kengaku@icems.kyoto-u.ac.jp.
  • Nakao K; Department of Molecular Engineering , Graduate School of Engineering , Kyoto University , Nishikyo-ku , Kyoto 615-8510 , Japan . Email: imahori@scl.kyoto-u.ac.jp.
  • Grove WD; Department of Molecular Engineering , Graduate School of Engineering , Kyoto University , Nishikyo-ku , Kyoto 615-8510 , Japan . Email: imahori@scl.kyoto-u.ac.jp.
  • Inoue R; Institute for Integrated Cell-Material Sciences (WPI-iCeMS) , Kyoto University , Sakyo-ku , Kyoto 606-8501 , Japan . Email: kengaku@icems.kyoto-u.ac.jp.
  • Kengaku M; Department of Physiology , Graduate School of Medical Sciences , Fukuoka University , Nanakuma 7-45-1, Johnan-ku , Fukuoka 814-0180 , Japan.
  • Sakaki S; Institute for Integrated Cell-Material Sciences (WPI-iCeMS) , Kyoto University , Sakyo-ku , Kyoto 606-8501 , Japan . Email: kengaku@icems.kyoto-u.ac.jp.
  • Mori Y; Fukui Institute for Fundamental Chemistry , Kyoto University , Sakyo-ku , Kyoto 606-8103 , Japan.
  • Murakami T; Department of Synthetic Chemistry and Biological Chemistry , Graduate School of Engineering , Kyoto University , Nishikyo-ku , Kyoto 615-8510 , Japan . Email: mori@sbchem.kyoto-u.ac.jp.
  • Imahori H; Institute for Integrated Cell-Material Sciences (WPI-iCeMS) , Kyoto University , Sakyo-ku , Kyoto 606-8501 , Japan . Email: kengaku@icems.kyoto-u.ac.jp.
Chem Sci ; 7(5): 3331-3337, 2016 May 01.
Article em En | MEDLINE | ID: mdl-29997826
ABSTRACT
A series of porphyrin-fullerene linked molecules has been synthesized to evaluate the effects of substituents and molecular structures on their charge-separation yield and the lifetime of a final charge-separated state in various hydrophilic environments. The selected high-performance molecule effectively achieved depolarization in a plasma cell membrane by visible light as well as two-photon excitation using a near-infrared light laser. Moreover, it was revealed that the depolarization can trigger neuronal firing in rat hippocampal neurons, demonstrating the potential and versatility for controlling cell functions using light.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Chem Sci Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Chem Sci Ano de publicação: 2016 Tipo de documento: Article