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Contributions of medial prefrontal cortex to decision making involving risk of punishment.
Orsini, Caitlin A; Heshmati, Sara C; Garman, Tyler S; Wall, Shannon C; Bizon, Jennifer L; Setlow, Barry.
Afiliação
  • Orsini CA; Department of Psychiatry, University of Florida, Gainesville, FL, 32610, USA.
  • Heshmati SC; Department of Psychiatry, University of Florida, Gainesville, FL, 32610, USA.
  • Garman TS; Department of Neuroscience, University of Florida, Gainesville, FL, 32610, USA.
  • Wall SC; Department of Neuroscience, University of Florida, Gainesville, FL, 32610, USA.
  • Bizon JL; Department of Psychiatry, University of Florida, Gainesville, FL, 32610, USA; Department of Neuroscience, University of Florida, Gainesville, FL, 32610, USA; Center for Addiction Research and Education, University of Florida, Gainesville, FL, 32610, USA.
  • Setlow B; Department of Psychiatry, University of Florida, Gainesville, FL, 32610, USA; Department of Neuroscience, University of Florida, Gainesville, FL, 32610, USA; Center for Addiction Research and Education, University of Florida, Gainesville, FL, 32610, USA; Department of Psychology, University of Flori
Neuropharmacology ; 139: 205-216, 2018 09 01.
Article em En | MEDLINE | ID: mdl-30009836
The prefrontal cortex (PFC) plays an important role in several forms of cost-benefit decision making. Its contributions to decision making under risk of explicit punishment, however, are not well understood. A rat model was used to investigate the role of the medial PFC (mPFC) and its monoaminergic innervation in a Risky Decision-making Task (RDT), in which rats chose between a small, "safe" food reward and a large, "risky" food reward accompanied by varying probabilities of mild footshock punishment. Inactivation of mPFC increased choice of the large, risky reward when the punishment probability increased across the session ("ascending RDT"), but decreased choice of the large, risky reward when the punishment probability decreased across the session ("descending RDT"). In contrast, enhancement of monoamine availability via intra-mPFC amphetamine reduced choice of the large, risky reward only in the descending RDT. Systemic administration of amphetamine reduced choice of the large, risky reward in both the ascending and descending RDT; however, this reduction was not attenuated by concurrent mPFC inactivation, indicating that mPFC is not a critical locus of amphetamine's effects on risk taking. These findings suggest that mPFC plays an important role in adapting choice behavior in response to shifting risk contingencies, but not necessarily in risk-taking behavior per se.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Punição / Assunção de Riscos / Córtex Pré-Frontal / Tomada de Decisões Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Neuropharmacology Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Punição / Assunção de Riscos / Córtex Pré-Frontal / Tomada de Decisões Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Neuropharmacology Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos