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Deciphering the Role of Lipid Droplets in Cardiovascular Disease: A Report From the 2017 National Heart, Lung, and Blood Institute Workshop.
Goldberg, Ira J; Reue, Karen; Abumrad, Nada A; Bickel, Perry E; Cohen, Sarah; Fisher, Edward A; Galis, Zorina S; Granneman, James G; Lewandowski, E Douglas; Murphy, Robert; Olive, Michelle; Schaffer, Jean E; Schwartz-Longacre, Lisa; Shulman, Gerald I; Walther, Tobias C; Chen, Jue.
Afiliação
  • Goldberg IJ; New York University, New York City (I.J.G., E.A.F.).
  • Reue K; University of California, Los Angeles (K.R.).
  • Abumrad NA; Washington University in St. Louis, MO (N.A.A., J.E.S.).
  • Bickel PE; University of Texas Southwestern Medical Center, Dallas (P.E.B.).
  • Cohen S; University of North Carolina at Chapel Hill (S.C.).
  • Fisher EA; New York University, New York City (I.J.G., E.A.F.).
  • Galis ZS; National Institutes of Health/National, Heart, Lung, and Blood Institute, Bethesda, MD (Z.S.G., M.O., L.S.-L., J.C.).
  • Granneman JG; Wayne State University, Detroit, MI (J.G.G.).
  • Lewandowski ED; The Ohio State University Wexner Medical Center, Columbus (E.D.L.).
  • Murphy R; University of Colorado Denver (R.M.).
  • Olive M; National Institutes of Health/National, Heart, Lung, and Blood Institute, Bethesda, MD (Z.S.G., M.O., L.S.-L., J.C.).
  • Schaffer JE; Washington University in St. Louis, MO (N.A.A., J.E.S.).
  • Schwartz-Longacre L; National Institutes of Health/National, Heart, Lung, and Blood Institute, Bethesda, MD (Z.S.G., M.O., L.S.-L., J.C.).
  • Shulman GI; Yale University, Howard Hughes Medical Institute, New Haven, CT (G.I.S.).
  • Walther TC; Harvard University, Howard Hughes Medical Institute, Boston, MA (T.C.W.).
  • Chen J; National Institutes of Health/National, Heart, Lung, and Blood Institute, Bethesda, MD (Z.S.G., M.O., L.S.-L., J.C.). jue.chen@nih.gov.
Circulation ; 138(3): 305-315, 2018 07 17.
Article em En | MEDLINE | ID: mdl-30012703
ABSTRACT
Lipid droplets (LDs) are distinct and dynamic organelles that affect the health of cells and organs. Much progress has been made in understanding how these structures are formed, how they interact with other cellular organelles, how they are used for storage of triacylglycerol in adipose tissue, and how they regulate lipolysis. Our understanding of the biology of LDs in the heart and vascular tissue is relatively primitive in comparison with LDs in adipose tissue and liver. The National Heart, Lung, and Blood Institute convened a working group to discuss how LDs affect cardiovascular diseases. The goal of the working group was to examine the current state of knowledge on the cell biology of LDs, including current methods to study them in cells and organs and reflect on how LDs influence the development and progression of cardiovascular diseases. This review summarizes the working group discussion and recommendations on research areas ripe for future investigation that will likely improve our understanding of atherosclerosis and heart function.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Gotículas Lipídicas / Miocárdio Limite: Animals / Humans País/Região como assunto: America do norte Idioma: En Revista: Circulation Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Gotículas Lipídicas / Miocárdio Limite: Animals / Humans País/Região como assunto: America do norte Idioma: En Revista: Circulation Ano de publicação: 2018 Tipo de documento: Article