A facile method for the synthesis of 2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid and it's optimization.
Pak J Pharm Sci
; 31(4): 1393-1397, 2018 Jul.
Article
em En
| MEDLINE
| ID: mdl-30033425
ABSTRACT
2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid (IV), a key intermediate of saxagliptin for type 2 diabetes mellitus (T2DM), was prepared from 1-adamantanecarboxylic acid(I) via oxidation by potassium permanganate(KMnO4) to afford 3-hydroxy-1-adamantanecarboxylic acid (II), which was treated with a one-pot method to give 1-acetyl-3-hydroxyadamantane (III) followed by oxidation. Some key steps were optimized and the overall yield was about 51%.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adamantano
/
Dipeptídeos
/
Técnicas de Química Sintética
/
Hipoglicemiantes
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Acetatos
Idioma:
En
Revista:
Pak J Pharm Sci
Assunto da revista:
FARMACIA
/
FARMACOLOGIA
/
QUIMICA
Ano de publicação:
2018
Tipo de documento:
Article