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Prospective observations study protocol to investigate cost-effectiveness of various prenatal test strategies after the introduction of noninvasive prenatal testing.
Kim, So Yeon; Lee, Seung Mi; Jun, Jong Kwan; Han, You Jung; Kim, Min Hyoung; Shim, Jae-Yoon; Lee, Mi-Young; Oh, Soo-Young; Lee, JoonHo; Kim, Soo Hyun; Cha, Dong Hyun; Cho, Geum Joon; Kwon, Han-Sung; Kim, Byoung Jae; Park, Mi Hye; Cho, Hee Young; Ko, Hyun Sun; Ahn, Jeonghoon; Ryu, Hyun Mee.
Afiliação
  • Kim SY; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • Lee SM; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea. smleemd@hanmail.net.
  • Jun JK; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • Han YJ; Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine, Seoul, Republic of Korea.
  • Kim MH; Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine, Seoul, Republic of Korea.
  • Shim JY; Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
  • Lee MY; Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
  • Oh SY; Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  • Lee J; Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine, Yonsei University Health System, Seoul, Republic of Korea.
  • Kim SH; Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Republic of Korea.
  • Cha DH; Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Republic of Korea.
  • Cho GJ; Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Republic of Korea.
  • Kwon HS; Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul, Republic of Korea.
  • Kim BJ; Department of Obstetrics and Gynecology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Republic of Korea.
  • Park MH; Department of Obstetrics and Gynecology, Ewha Womans University, Seoul, Republic of Korea.
  • Cho HY; Department of Obstetrics and Gynecology, Bundang CHA Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea.
  • Ko HS; Department of Obstetrics and Gynecology, Catholic University of Korea College of Medicine, Seoul, Republic of Korea.
  • Ahn J; Department of Health Convergence, Ewha Womans University, Seoul, Republic of Korea.
  • Ryu HM; Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine, Seoul, Republic of Korea. hmryu2012@naver.com.
BMC Pregnancy Childbirth ; 18(1): 307, 2018 Jul 24.
Article em En | MEDLINE | ID: mdl-30041617
BACKGROUND: Among the non-invasive screening methods for the identification of fetal aneuploidy, NIPT (non-invasive prenatal testing) shows the highest sensitivity and specificity in high-risk pregnancies. Due to the low false positive rate of NIPT, it is assumed that the implementation of NIPT as a primary screening method may reduce the number of invasive fetal tests and result in a similar or lowered cost in the overall detection of Down syndrome. However, most previous studies are based on theoretical economic analysis. This study aims to determine the cost effectiveness of various prenatal test strategies, including NIPT, in real clinical settings in both low risk and high risk pregnancies. METHODS/DESIGN: In this prospective observational study, women (< 24 weeks) with singleton or twin pregnancies will be enrolled in 12 different healthcare institutions. The participants will be grouped based on the risks of fetal chromosomal abnormalities and will be counseled on the various screening or diagnostic methods, including NIPT, according to the aneuploidy risk. The final decision on screening or diagnostic methods will be made by patients after counseling. Questionnaires regarding factors affecting the decision on prenatal test will be answered by the participants and physicians. The economic analysis on final total costs will be compared according to the various prenatal test strategies. DISCUSSION: The results of present study are expected to have a significant impact on national policies in determining Korean prenatal screening test strategies and to help in developing novel and effective prenatal screening tests in the future.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diagnóstico Pré-Natal / Testes Genéticos / Análise Custo-Benefício / Transtornos Cromossômicos / Estudos Observacionais como Assunto / Aneuploidia Tipo de estudo: Diagnostic_studies / Health_economic_evaluation / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy País/Região como assunto: Asia Idioma: En Revista: BMC Pregnancy Childbirth Assunto da revista: OBSTETRICIA Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diagnóstico Pré-Natal / Testes Genéticos / Análise Custo-Benefício / Transtornos Cromossômicos / Estudos Observacionais como Assunto / Aneuploidia Tipo de estudo: Diagnostic_studies / Health_economic_evaluation / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy País/Região como assunto: Asia Idioma: En Revista: BMC Pregnancy Childbirth Assunto da revista: OBSTETRICIA Ano de publicação: 2018 Tipo de documento: Article