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Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19).
Barouch, Dan H; Tomaka, Frank L; Wegmann, Frank; Stieh, Daniel J; Alter, Galit; Robb, Merlin L; Michael, Nelson L; Peter, Lauren; Nkolola, Joseph P; Borducchi, Erica N; Chandrashekar, Abishek; Jetton, David; Stephenson, Kathryn E; Li, Wenjun; Korber, Bette; Tomaras, Georgia D; Montefiori, David C; Gray, Glenda; Frahm, Nicole; McElrath, M Juliana; Baden, Lindsey; Johnson, Jennifer; Hutter, Julia; Swann, Edith; Karita, Etienne; Kibuuka, Hannah; Mpendo, Juliet; Garrett, Nigel; Mngadi, Kathy; Chinyenze, Kundai; Priddy, Frances; Lazarus, Erica; Laher, Fatima; Nitayapan, Sorachai; Pitisuttithum, Punnee; Bart, Stephan; Campbell, Thomas; Feldman, Robert; Lucksinger, Gregg; Borremans, Caroline; Callewaert, Katleen; Roten, Raphaele; Sadoff, Jerald; Scheppler, Lorenz; Weijtens, Mo; Feddes-de Boer, Karin; van Manen, Daniëlle; Vreugdenhil, Jessica; Zahn, Roland; Lavreys, Ludo.
Afiliação
  • Barouch DH; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. Electronic address: dbarouch@bidmc.harvard.edu.
  • Tomaka FL; Janssen Research and Development, Titusville, NJ, USA.
  • Wegmann F; Janssen Vaccines & Prevention BV, Leiden, Netherlands.
  • Stieh DJ; Janssen Vaccines & Prevention BV, Leiden, Netherlands.
  • Alter G; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
  • Robb ML; Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA; Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • Michael NL; Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Peter L; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Nkolola JP; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Borducchi EN; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Chandrashekar A; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Jetton D; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Stephenson KE; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
  • Li W; University of Massachusetts Medical School, Worcester, MA, USA.
  • Korber B; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, USA.
  • Tomaras GD; Department of Surgery and Duke Human Vaccine Institute, Duke University, Durham, NC, USA.
  • Montefiori DC; Department of Surgery and Duke Human Vaccine Institute, Duke University, Durham, NC, USA.
  • Gray G; Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Frahm N; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • McElrath MJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Baden L; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Johnson J; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Hutter J; Vaccine Clinical Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Swann E; Vaccine Clinical Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Karita E; Project San Francisco, Rwanda-Zambia HIV Research Group, Kigali, Rwanda.
  • Kibuuka H; Makerere University Walter Reed Project, Kampala, Uganda.
  • Mpendo J; Uganda Virus Research Institute, International AIDS Vaccine Initiative HIV Vaccine Program, Entebbe, Uganda.
  • Garrett N; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.
  • Mngadi K; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.
  • Chinyenze K; International AIDS Vaccine Initiative, New York City, NY, USA.
  • Priddy F; International AIDS Vaccine Initiative, New York City, NY, USA.
  • Lazarus E; Department of Surgery and Duke Human Vaccine Institute, Duke University, Durham, NC, USA.
  • Laher F; Department of Surgery and Duke Human Vaccine Institute, Duke University, Durham, NC, USA.
  • Nitayapan S; Royal Thai Army, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
  • Pitisuttithum P; The Vaccine Trial Center, Faculty of Tropical Medicine, Mahidol University, Bangkok.
  • Bart S; Optimal Research, LLC, Rockville, MD, USA.
  • Campbell T; University of Colorado, Denver, CO, USA.
  • Feldman R; Miami Research Associates, Miami, FL, USA.
  • Lucksinger G; Tekton Research, Austin, TX, USA.
  • Borremans C; Janssen Infectious Diseases BV, Beerse, Belgium.
  • Callewaert K; Janssen Infectious Diseases BV, Beerse, Belgium.
  • Roten R; Janssen Infectious Diseases BV, Beerse, Belgium.
  • Sadoff J; Janssen Vaccines & Prevention BV, Leiden, Netherlands.
  • Scheppler L; Janssen Vaccines & Prevention BV, Leiden, Netherlands; Janssen Infectious Diseases BV, Beerse, Belgium.
  • Weijtens M; Janssen Vaccines & Prevention BV, Leiden, Netherlands.
  • Feddes-de Boer K; Janssen Vaccines & Prevention BV, Leiden, Netherlands.
  • van Manen D; Janssen Vaccines & Prevention BV, Leiden, Netherlands.
  • Vreugdenhil J; Janssen Vaccines & Prevention BV, Leiden, Netherlands.
  • Zahn R; Janssen Vaccines & Prevention BV, Leiden, Netherlands.
  • Lavreys L; Janssen Infectious Diseases BV, Beerse, Belgium.
Lancet ; 392(10143): 232-243, 2018 07 21.
Article em En | MEDLINE | ID: mdl-30047376
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: HIV-1 / Vacinas contra a AIDS Tipo de estudo: Clinical_trials / Etiology_studies / Guideline Limite: Adolescent / Adult / Animals / Humans / Middle aged Idioma: En Revista: Lancet Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: HIV-1 / Vacinas contra a AIDS Tipo de estudo: Clinical_trials / Etiology_studies / Guideline Limite: Adolescent / Adult / Animals / Humans / Middle aged Idioma: En Revista: Lancet Ano de publicação: 2018 Tipo de documento: Article