Centrally administered beta-endorphin produces prolonged changes in delta-opioid ligand activity in vivo.
Eur J Pharmacol
; 120(3): 359-62, 1986 Jan 29.
Article
em En
| MEDLINE
| ID: mdl-3005007
ABSTRACT
Spontaneous reflex bladder contractions were recorded isometrically in urethane anesthetized rats. Bladder contractions were depressed by intracerebroventricular injections of the mu-opioid receptor agonist [D-Ala2,MePhe4,Gly(ol)5]enkephalin (DAGO) and the delta-agonist [2D-penicillamine,5D-penicillamine]enkephalin (DPDPE) respectively. The effect of DPDPE was selectively antagonized by ICI 174,864 (N,N-diallyl-Tyr-Aib-Aib-Phe-Leu-OH; Aib = alpha-aminoisobutyric acid). However following the administration of beta-endorphin the antagonistic action of ICI 174,864 could no longer be observed. In addition ICI 174,864 exhibited agonistic activity following beta-endorphin and the effects of DPDPE were prolonged in a dose related manner by beta-endorphin. These observations suggest that beta-endorphin may produce complex changes in central delta-opioid receptor activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Endorfinas
/
Receptores Opioides
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
1986
Tipo de documento:
Article