Breadth of coverage against a panel of 110 invasive disease isolates, immunogenicity and safety for 2 and 3 doses of an investigational MenABCWY vaccine in US adolescents - Results from a randomized, controlled, observer-blind phase II study.

Welsch, Jo Anne; Senders, Shelly; Essink, Brandon; Klein, Thomas; Smolenov, Igor; Pedotti, Paola; Barbi, Silvia; Verma, Bikash; Toneatto, Daniela

Welsch, Jo Anne; Senders, Shelly; Essink, Brandon; Klein, Thomas; Smolenov, Igor; Pedotti, Paola; Barbi, Silvia; Verma, Bikash; Toneatto, Daniela.

Afiliação

Welsch JA; GSK, 14200 Shady Grove Road, Rockville, MD 20850, United States. Electronic address: jwelsch@path.org.
Senders S; Senders Pediatrics, 2054 South Green Road, South Euclid, OH 44121, United States. Electronic address: ssenders@senderspediatrics.com.
Essink B; Meridian Clinical Research, 3323 N 107th St, Omaha, NE 68134, United States. Electronic address: bessink@mcrmed.com.
Klein T; Family Medicine East, Chtd, 1709 S Rock Rd, Wichita, KS 67207-5150, United States. Electronic address: tck@heartlandresearch.com.
Smolenov I; GSK, Hullenbergweg 81-89, 1101 CL Amsterdam, The Netherlands. Electronic address: smolenov@gmail.com.
Pedotti P; GSK, Hullenbergweg 81-89, 1101 CL Amsterdam, The Netherlands. Electronic address: paola.x.pedotti@gsk.com.
Barbi S; GSK, Hullenbergweg 81-89, 1101 CL Amsterdam, The Netherlands. Electronic address: silvia.x.barbi@gsk.com.
Verma B; GSK, 350 Massachusetts Ave, Cambridge, 02139 MA, United States. Electronic address: bikashverma@usa.com.
Toneatto D; GSK, Via Fiorentina, 1, 53100 Siena, Italy. Electronic address: daniela.x.toneatto@gsk.com.

Vaccine ; 36(35): 5309-5317, 2018 08 23.

Article em En | MEDLINE | ID: mdl-30061029

Assuntos

Infecções Meningocócicas/prevenção & controle; Vacinas Meningocócicas/imunologia; Vacinas Meningocócicas/uso terapêutico; Adolescente; Criança; Feminino; Humanos; Masculino; Infecções Meningocócicas/imunologia; Vacinas Meningocócicas/metabolismo; Neisseria meningitidis/imunologia; Neisseria meningitidis/patogenicidade; Sorogrupo; Vacinas Combinadas; Vacinas Conjugadas/imunologia; Vacinas Conjugadas/uso terapêutico

Palavras-chave

Adolescents; Breadth of coverage; Endogenous complement human bactericidal assay; MenABCWY; Meningococcal vaccine; Neisseria meningitidis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas Meningocócicas / Infecções Meningocócicas Tipo de estudo: Clinical_trials / Etiology_studies Limite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Vaccine Ano de publicação: 2018 Tipo de documento: Article

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