A systematic review of Drosophila short-term-memory genetics: Meta-analysis reveals robust reproducibility.
Neurosci Biobehav Rev
; 95: 361-382, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-30077573
ABSTRACT
Geneticists use olfactory conditioning in Drosophila to identify learning genes; however, little is known about how these genes are integrated into short-term memory (STM) pathways. Here, we investigated the hypothesis that the STM evidence base is weak. We performed systematic review and meta-analysis of the field. Using metrics to quantify variation between discovery articles and follow-up studies, we found that seven genes were both highly replicated, and highly reproducible. However, â¼80% of STM genes have never been replicated. While only a few studies investigated interactions, the reviewed genes could account for >1000% memory. This large summed effect size could indicate irreproducibility, many shared pathways, or that current assay protocols lack the specificity needed to identify core plasticity genes. Mechanistic theories of memory will require the convergence of evidence from system, circuit, cellular, molecular, and genetic experiments; systematic data synthesis is an essential tool for integrated neuroscience.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Drosophila
/
Memória de Curto Prazo
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Systematic_reviews
Limite:
Animals
Idioma:
En
Revista:
Neurosci Biobehav Rev
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Singapura