Paclitaxel Sensitivity of Ovarian Cancer Can be Enhanced by Knocking Down Pairs of Kinases that Regulate MAP4 Phosphorylation and Microtubule Stability.

Yang, Hailing; Mao, Weiqun; Rodriguez-Aguayo, Cristian; Mangala, Lingegowda S; Bartholomeusz, Geoffrey; Iles, Lakesla R; Jennings, Nicholas B; Ahmed, Ahmed Ashour; Sood, Anil K; Lopez-Berestein, Gabriel; Lu, Zhen; Bast, Robert C

Yang, Hailing; Mao, Weiqun; Rodriguez-Aguayo, Cristian; Mangala, Lingegowda S; Bartholomeusz, Geoffrey; Iles, Lakesla R; Jennings, Nicholas B; Ahmed, Ahmed Ashour; Sood, Anil K; Lopez-Berestein, Gabriel; Lu, Zhen; Bast, Robert C.

Afiliação

Yang H; Department of Experimental Therapeutics, University of Texas, M.D. Anderson Cancer Center, Houston, Texas.
Mao W; Department of Experimental Therapeutics, University of Texas, M.D. Anderson Cancer Center, Houston, Texas.
Rodriguez-Aguayo C; Department of Experimental Therapeutics, University of Texas, M.D. Anderson Cancer Center, Houston, Texas.
Mangala LS; Center for RNA Interference and Non-Coding RNA, University of Texas, M.D. Anderson Cancer Center, Houston, Texas.
Bartholomeusz G; Center for RNA Interference and Non-Coding RNA, University of Texas, M.D. Anderson Cancer Center, Houston, Texas.
Iles LR; Department of Gynecologic Oncology and Reproductive Medicine, University of Texas, M.D. Anderson Cancer Center, Houston, Texas.
Jennings NB; Department of Experimental Therapeutics, University of Texas, M.D. Anderson Cancer Center, Houston, Texas.
Ahmed AA; Department of Experimental Therapeutics, University of Texas, M.D. Anderson Cancer Center, Houston, Texas.
Sood AK; Center for RNA Interference and Non-Coding RNA, University of Texas, M.D. Anderson Cancer Center, Houston, Texas.
Lopez-Berestein G; Ovarian Cancer Cell Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford, United Kingdom.
Lu Z; Nuffield Department of Women's & Reproductive Health, University of Oxford, Women's Centre, John Radcliffe Hospital, Oxford, United Kingdom.
Bast RC; Center for RNA Interference and Non-Coding RNA, University of Texas, M.D. Anderson Cancer Center, Houston, Texas.

Clin Cancer Res ; 24(20): 5072-5084, 2018 10 15.

Article em En | MEDLINE | ID: mdl-30084832

Assuntos

Resistencia a Medicamentos Antineoplásicos/genética; Proteínas Associadas aos Microtúbulos/metabolismo; Microtúbulos/metabolismo; Neoplasias Ovarianas/genética; Neoplasias Ovarianas/metabolismo; Paclitaxel/farmacologia; Proteínas Quinases/genética; Animais; Antineoplásicos Fitogênicos/farmacologia; Apoptose/efeitos dos fármacos; Biomarcadores; Ciclo Celular/genética; Linhagem Celular Tumoral; Modelos Animais de Doenças; Feminino; Técnicas de Silenciamento de Genes; Genes BRCA1; Genes BRCA2; Genes p53; Humanos; Camundongos; Mutação; Neoplasias Ovarianas/tratamento farmacológico; Fosforilação; RNA Interferente Pequeno/genética; Ensaios Antitumorais Modelo de Xenoenxerto; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Proteínas Quinases / Paclitaxel / Resistencia a Medicamentos Antineoplásicos / Proteínas Associadas aos Microtúbulos / Microtúbulos Tipo de estudo: Diagnostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Clin Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2018 Tipo de documento: Article

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