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Neurochemical characterization of intramural nerve fibres in the porcine oesophagus.
Rytel, Liliana; Szymanska, Kamila; Gonkowski, Ignacy; Wojtkiewicz, Joanna.
Afiliação
  • Rytel L; Faculty of Veterinary Medicine, Department of Internal Disease with Clinic, University of Warmia and Mazury, Olsztyn, Poland.
  • Szymanska K; Faculty of Veterinary Medicine, Department of Clinical Physiology, University of Warmia and Mazury, Olsztyn, Poland.
  • Gonkowski I; Department of Pathophysiology, School of Medicine, University of Warmia and Mazury, Olsztyn, Poland.
  • Wojtkiewicz J; Department of Pathophysiology, School of Medicine, University of Warmia and Mazury, Olsztyn, Poland.
Anat Histol Embryol ; 47(6): 517-526, 2018 Dec.
Article em En | MEDLINE | ID: mdl-30105873
ABSTRACT
The gastrointestinal (GI) tract is innervated by nerve processes derived from the intramural enteric neurons and neurons localized outside the digestive tract. This study analysed the neurochemical characterization of nerves in the wall of the porcine oesophagus using single immunofluorescence technique. Immunoreactivity to vesicular acetylcholine transporter (VAChT), neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), somatostatin (SOM), galanin (GAL), neuronal isoform of nitric oxide synthase (nNOS), substance P (SP), leucine enkephalin (LENK), calcitonin gene-related peptide (CGRP) or dopamine beta-hydroxylase (DBH) was investigated in intramuscular and intramucosal nerves of the cervical, thoracic and abdominal oesophagus. The results indicate that all of the substances studied were present in the oesophageal nerves. The density of particular populations of fibres depended on the segment of the oesophagus. The most numerous were fibres immunoreactive to VIP in the longitudinal and circular muscle layers of the abdominal oesophagus The number of these fibres amounted to 16.4 ± 0.8 and 18.1 ± 3.1, respectively. In turn, the least numerous were CGRP-positive fibres, which were present only in the circular muscle layer of the cervical oesophagus and mucosal layer of the abdominal oesophagus in the number of 0.3 ± 0. The obtained results show that nerves in the porcine oesophageal wall are very diverse in their neurochemical coding, and differences between particular parts of the oesophagus suggest that organization of the innervation clearly depends on the fragment of this organ.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neuropeptídeos / Imunofluorescência / Sistema Nervoso Entérico / Esôfago / Fibras Nervosas Limite: Animals Idioma: En Revista: Anat Histol Embryol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Polônia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neuropeptídeos / Imunofluorescência / Sistema Nervoso Entérico / Esôfago / Fibras Nervosas Limite: Animals Idioma: En Revista: Anat Histol Embryol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Polônia