Subclinical metabolic and cardiovascular abnormalities in autosomal dominant polycystic kidney diseaseâ©.
Clin Nephrol
; 90(4): 237-245, 2018 Oct.
Article
em En
| MEDLINE
| ID: mdl-30106364
ABSTRACT
Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent genetic kidney disease. It carries high lifetime morbidity not only due to chronic kidney disease, but also due to a higher risk of cardiovascular death. Multiple metabolic abnormalities associated with ADPKD including insulin resistance and hyperlipidemia as well as subclinical cardiovascular abnormalities, such as left ventricular hypertrophy (LVH), contribute to this cardiovascular risk. These conditions may manifest before evidence of worsening estimated glomerular filtration rate (eGFR). Renal oxidative stress also occurs early in the disease and is a driver of ADPKD progression. Animal models have shown that calorie restriction may mitigate these inflammatory processes. Further research is required to show whether attenuation of metabolic abnormalities associated with ADPKD may improve renal and cardiovascular morbidity.â©.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resistência à Insulina
/
Rim Policístico Autossômico Dominante
/
Hipertrofia Ventricular Esquerda
/
Metabolismo dos Lipídeos
Tipo de estudo:
Etiology_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Clin Nephrol
Ano de publicação:
2018
Tipo de documento:
Article