Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes.

Van Hoecke, Lien; Van Lint, Sandra; Roose, Kenny; Van Parys, Alexander; Vandenabeele, Peter; Grooten, Johan; Tavernier, Jan; De Koker, Stefaan; Saelens, Xavier

Van Hoecke, Lien; Van Lint, Sandra; Roose, Kenny; Van Parys, Alexander; Vandenabeele, Peter; Grooten, Johan; Tavernier, Jan; De Koker, Stefaan; Saelens, Xavier.

Afiliação

Van Hoecke L; VIB Center for Medical Biotechnology, VIB, 9000, Ghent, Belgium.
Van Lint S; Department of Biomedical Molecular Biology, Ghent University, 9000, Ghent, Belgium.
Roose K; VIB Center for Medical Biotechnology, VIB, 9000, Ghent, Belgium.
Van Parys A; Cytokine Receptor Laboratory, Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, 9000, Ghent, Belgium.
Vandenabeele P; VIB Center for Medical Biotechnology, VIB, 9000, Ghent, Belgium.
Grooten J; Department of Biomedical Molecular Biology, Ghent University, 9000, Ghent, Belgium.
Tavernier J; VIB Center for Medical Biotechnology, VIB, 9000, Ghent, Belgium.
De Koker S; Cytokine Receptor Laboratory, Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, 9000, Ghent, Belgium.
Saelens X; Department of Biomedical Molecular Biology, Ghent University, 9000, Ghent, Belgium.

Nat Commun ; 9(1): 3417, 2018 08 24.

Article em En | MEDLINE | ID: mdl-30143632

Assuntos

Imunoterapia/métodos; Necrose/metabolismo; Neoplasias/terapia; Proteínas Quinases/genética; RNA Mensageiro/genética; Animais; Apoptose/genética; Apoptose/fisiologia; Linhagem Celular; Feminino; Humanos; Linfoma/imunologia; Linfoma/terapia; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Endogâmicos C57BL; Necrose/genética; Neoplasias/genética; Modelos de Riscos Proporcionais; Transdução de Sinais/genética; Transdução de Sinais/fisiologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Quinases / RNA Mensageiro / Imunoterapia / Necrose / Neoplasias Limite: Animals / Female / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Bélgica

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