Postoperative serum CA19-9, CEA and CA125 predicts the response to adjuvant chemoradiotherapy following radical resection in pancreatic adenocarcinoma.
Pancreatology
; 18(6): 671-677, 2018 Sep.
Article
em En
| MEDLINE
| ID: mdl-30153903
ABSTRACT
OBJECTIVE:
To evaluate the prediction of benefits from adjuvant chemoradiotherapy by postoperative serum CA19-9, CA125 and CEA.METHODS:
The relations between benefits from adjuvant chemoradiotherapy and levels of postoperative serum CA19-9, CA125 and CEA were investigated in 804 pancreatic adenocarcinoma patients who received radical resection.RESULTS:
Adjuvant chemoradiotherapy was an independent factor for late recurrence [12.2 vs. 8.5 months, Pâ¯=â¯0.001 for recurrence free survival (RFS)] and long survival [23.7 vs. 17.0 months, Pâ¯<â¯0.001 for overall survival (OS)] in resected pancreatic adenocarcinoma. Postoperative serum CA19-9, CA125 and CEA were independent risk predictors for poor surgical outcome in pancreatic adenocarcinoma (Pâ¯<â¯0.001 for all). Adjuvant chemradiotherapy (hazard ratio 0.359, 95% confidence interval 0.253-0.510, Pâ¯<â¯0.001 for OS; hazard ratio 0.522, 95% confidence interval 0.387-0.705, Pâ¯<â¯0.001 for RFS) were confirmed to improve the surgical outcome in patients with abnormal levels of any one of the three postoperative markers, but not in patients with normal levels of the three postoperative markers. In the subgroup of patients with negative lymph node, its improvement of surgical outcome was also significant in patients with abnormal levels of any one of postoperative serum CA19-9, CA125 and CEA (hazard ratio 0.412, 95% confidence interval 0.244-0.698, Pâ¯=â¯0.001 for OS; hazard ratio 0.546, 95% confidence interval 0.352-0.847, Pâ¯=â¯0.007 for RFS).CONCLUSION:
Postoperative serum CA19-9, CA125 and CEA could serve as predictors of response for adjuvant chemoradiotherapy even if the status of lymph nodes is negative.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
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Adenocarcinoma
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Antígeno Carcinoembrionário
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Biomarcadores Tumorais
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Antígeno CA-19-9
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Antígeno Ca-125
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Quimiorradioterapia Adjuvante
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Proteínas de Membrana
Tipo de estudo:
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
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Aged80
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Pancreatology
Assunto da revista:
ENDOCRINOLOGIA
/
GASTROENTEROLOGIA
Ano de publicação:
2018
Tipo de documento:
Article