Distinct pathways of viral spread in the host determined by reovirus S1 gene segment.
Science
; 233(4765): 770-4, 1986 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-3016895
ABSTRACT
The genetic and molecular mechanisms that determine the capacity of a virus to utilize distinct pathways of spread in an infected host were examined by using reoviruses. Both reovirus type 1 and reovirus type 3 spread to the spinal cord following inoculation into the hindlimb or forelimb footpad of newborn mice. For type 3 this spread is through nerves and occurs via the microtubule-associated system of fast axonal transport. By contrast, type 1 spreads to the spinal cord through the bloodstream. With the use of reassortant viruses containing various combinations of double-stranded RNA segments (genes) derived from type 1 and type 3, the viral S1 double-stranded RNA segment was shown to be responsible for determining the capacity of reoviruses to spread to the central nervous system through these distinct pathways.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reoviridae
/
Orthoreovirus Mamífero 3
/
Medula Espinal
/
Genes Virais
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1986
Tipo de documento:
Article