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Effect of Chain Unsaturation and Temperature on Oxygen Diffusion Through Lipid Membranes from Simulations.
De Vos, Oriana; Van Hecke, Tanja; Ghysels, An.
Afiliação
  • De Vos O; Center for Molecular Modeling, Ghent University, Ghent, Belgium.
  • Van Hecke T; Department of Information Technology, Faculty of Engineering and Architecture, Ghent University, Ghent, Belgium.
  • Ghysels A; Center for Molecular Modeling, Ghent University, Ghent, Belgium. An.Ghysels@UGent.be.
Adv Exp Med Biol ; 1072: 399-404, 2018.
Article em En | MEDLINE | ID: mdl-30178378
Rafts are nanoscale ordered domains in biological membranes that are rich in saturated phospholipids. In this study, the influence of chain unsaturation and temperature on oxygen diffusion through lipid membranes is examined using advanced computational modeling. The studied phospholipids with increasing unsaturation are: 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC). The unsaturation correlates with the area per lipid and the order parameter. Oxygen diffusion is found to be faster at higher temperature, and the solubility of oxygen in the membrane with respect to water decreases. Diffusion varies over a larger range across the membrane at 323 K in DPPC than in DOPC, whereas POPC has intermediate diffusivity. Oxygen diffusion in saturated lipids is faster at the membrane center and slower near the head group region than in unsaturated lipids. Oxygen solubility in DPPC is higher than in unsaturated lipids.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxigênio / Simulação por Computador / Microdomínios da Membrana Limite: Humans Idioma: En Revista: Adv Exp Med Biol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Bélgica

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxigênio / Simulação por Computador / Microdomínios da Membrana Limite: Humans Idioma: En Revista: Adv Exp Med Biol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Bélgica