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Development of a physiologically based pharmacokinetic model for mefloquine and its application alongside a clinical effectiveness model to select an optimal dose for prevention of malaria in young Caucasian children.
Johnson, Trevor N; Cleary, Yumi; Parrott, Neil; Reigner, Bruno; Smith, James R; Toovey, Stephen.
Afiliação
  • Johnson TN; Certara UK Limited (Simcyp) Level 2-Acero, 1 Concourse Way, Sheffield, UK.
  • Cleary Y; Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
  • Parrott N; Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
  • Reigner B; Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
  • Smith JR; Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
  • Toovey S; Pegasus Research, Basel, Switzerland.
Br J Clin Pharmacol ; 85(1): 100-113, 2019 01.
Article em En | MEDLINE | ID: mdl-30198595
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mefloquina / Malária / Modelos Biológicos / Antimaláricos Tipo de estudo: Prognostic_studies Limite: Adult / Child / Child, preschool / Female / Humans / Infant / Middle aged Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mefloquina / Malária / Modelos Biológicos / Antimaláricos Tipo de estudo: Prognostic_studies Limite: Adult / Child / Child, preschool / Female / Humans / Infant / Middle aged Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido