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Can hair steroids predict pregnancy longevity?
Schonblum, Anat; Arnon, Liat; Ravid, Eyal; Salzer, Liat; Hadar, Eran; Meizner, Israel; Wiznitzer, Arnon; Weller, Aron; Koren, Lee.
Afiliação
  • Schonblum A; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel.
  • Arnon L; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel.
  • Ravid E; The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Salzer L; Helen Schneider's Hospital for Women, Rabin Medical Center, Petah-Tikva 49100, Israel; The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Hadar E; Helen Schneider's Hospital for Women, Rabin Medical Center, Petah-Tikva 49100, Israel; The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Meizner I; Helen Schneider's Hospital for Women, Rabin Medical Center, Petah-Tikva 49100, Israel; The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Wiznitzer A; Helen Schneider's Hospital for Women, Rabin Medical Center, Petah-Tikva 49100, Israel; The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Weller A; Department of Psychology and Gonda Brain Research Center, Bar-Ilan University, Ramat Gan, 5290002, Israel.
  • Koren L; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel. Electronic address: Lee.Koren@biu.ac.il.
Reprod Biol ; 18(4): 410-415, 2018 Dec.
Article em En | MEDLINE | ID: mdl-30219333
Maintaining pregnancy to term is important as preterm delivery is a risk factor for impaired infant development, which may have negative long-term consequences. Therefore, developing biomarkers that can predict pregnancy longevity during early gestation is essential for the prevention of preterm birth. Here we explored whether maternal hair testosterone and cortisol, representing the pre-conception and first trimester periods respectively, may be used to predict pregnancy longevity. We recruited 125 pregnant women that contributed hair samples and answered a personal information questionnaire that included pre-conception smoking. We quantified steroids using commercial enzyme-linked immunosorbent assay kits. Gestational age at delivery was obtained from medical records. We used General Linear Models to predict gestation length. The model that included first trimester cortisol, pre-conception smoking, pre-conception testosterone and the interaction between first trimester cortisol and pre-conception smoking predicted 13% of the variance in gestation length (R2 = 0.130; n = 105; p = 0.007). First trimester cortisol was the best predictor of gestational length. Women with high levels of cortisol in their first trimester had an increased probability of a full-term delivery. The effect of cortisol was especially pronounced in smokers (ß = 1.69), compared to non-smokers (ß = 0.45). Pre-conception testosterone also contributed to the model. Our study suggests that hair steroids may be used to predict pregnancy longevity, together with other contributing factors.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testosterona / Hidrocortisona / Cabelo Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Reprod Biol Assunto da revista: MEDICINA REPRODUTIVA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Israel

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testosterona / Hidrocortisona / Cabelo Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Reprod Biol Assunto da revista: MEDICINA REPRODUTIVA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Israel