Roles for ER:endosome membrane contact sites in ligand-stimulated intraluminal vesicle formation.
Biochem Soc Trans
; 46(5): 1055-1062, 2018 10 19.
Article
em En
| MEDLINE
| ID: mdl-30242114
ABSTRACT
Multivesicular endosomes/bodies (MVBs) sort membrane proteins between recycling and degradative pathways. Segregation of membrane proteins onto intraluminal vesicles (ILVs) of MVBs removes them from the recycling pathway and facilitates their degradation following fusion of MVBs with lysosomes. Sorting of many cargos onto ILVs depends on the ESCRT (Endosomal Sorting Complex Required for Transport) machinery, although ESCRT-independent mechanisms also exist. In mammalian cells, efficient sorting of ligand-stimulated epidermal growth factor receptors onto ILVs also depends on the tyrosine phosphatase, PTP1B, an ER-localised enzyme that interacts with endosomal targets at membrane contacts between MVBs and the ER. This review focuses on the potential roles played by ERMVB membrane contact sites in regulating ESCRT-dependent ILV formation.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Endossomos
/
Retículo Endoplasmático
/
Corpos Multivesiculares
/
Complexos Endossomais de Distribuição Requeridos para Transporte
/
Lisossomos
Limite:
Humans
Idioma:
En
Revista:
Biochem Soc Trans
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Reino Unido