The association of hemocyte profile and obstructive sleep apnea.
J Clin Lab Anal
; 33(2): e22680, 2019 Feb.
Article
em En
| MEDLINE
| ID: mdl-30246267
ABSTRACT
BACKGROUND:
The hemocyte profile is one of the most frequently requested clinical laboratory tests. However, the analysis of blood cell indexes of obstructive sleep apnea (OSA) patients in previous studies was not comprehensive. And, this study aimed to fully analyze the blood routine in OSA patients.METHODS:
A retrospective study was conducted on 1087 male patients, who were admitted to the sleep center of Nanfang Hospital from May 2013 to February 2018. According to the apnea hypopnea index (AHI), patients were divided into four groups control group (AHI < 5, n = 135), mild OSA (5 ⦠AHI < 15, n = 185), moderate OSA (15 ⦠AHI < 30, n = 171), and severe OSA (AHI ⧠30, n = 596). Data collected included sleep parameters, complete blood routine, body mass index (BMI), age, and comorbidities.RESULTS:
In our study, leukocytes, neutrophils, lymphocytes, monocytes, eosinophils, basophils, erythrocytes, hemoglobin, hematocrit, platelets, MPV, and PDW-SD were statistically significant among the four groups based on AHI (P < 0.05), but no significant differences were found in MCV, RDW-SD, N/L, and P/L ratio (P > 0.05). Neutrophils, lymphocytes, monocytes, eosinophils, basophils, hemoglobin, hematocrit, platelets, and MPV were significantly correlated with AHI. Moreover, multiple linear regression analysis demonstrated that hematocrit (ß = 73.254, P = 0.001), neutrophils (ß = 1.414, P = 0.012), and lymphocytes (ß = 4.228, P < 0.001) were independently associated with AHI.CONCLUSION:
Neutrophils, lymphocytes, and hematocrit were independently associated with OSA severity. And combining these three blood cell indicators could contribute to the diagnosis of OSA.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Sanguíneas
/
Apneia Obstrutiva do Sono
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Clin Lab Anal
Assunto da revista:
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
China