Ferritin testing to characterize and address iron deficiency in young donors.
Transfusion
; 58(12): 2861-2867, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-30265754
ABSTRACT
BACKGROUND:
Iron deficiency is observed in blood donors who meet hemoglobin requirements for donation. Frequent donation results in negative iron balance, and teenage donors may thus be at risk for adverse health consequences. STUDY DESIGN ANDMETHODS:
Blood Systems implemented ferritin testing on all successful 16- to 18-year-old (teen) donations. Low ferritin (LF) was defined as less than 20 ng/mL in females and less than 30 ng/mL in males. Donors with LF were deferred from red blood cell (RBC) donations (12 months for females, and 6 for males) and counseled to take low-dose iron for 60 days. A ferritin value less than 26 ng/mL indicated iron-deficient erythropoiesis and less than 12 ng/mL absent iron stores.RESULTS:
Over 16 months, 110,417 teen donations were tested and represented 10.5% of all successful donations. The rate of absent iron stores was 9.0% (1.9% male; 15.9% female) and of iron-deficient erythropoiesis, 31.9% (12.4% male; 50.6% female). The rate of LF deferrals was 26.9% (16.7% male; 36.6% female). The proportion of LF donors decreased with increasing predonation hemoglobin and rose with increasing RBC donations in the prior 24 months. Seasonality in LF deferrals and the RBC contribution from teen donors was observed.CONCLUSIONS:
Ferritin testing of teen donors identified individuals with LF who might benefit from risk mitigation. LF is more common in teenage female than male donors and those with RBC donations in the prior 24 months. An appreciable number of new/lapsed donors presented with LF, however. These data may be useful in guiding future risk mitigation efforts.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doadores de Sangue
/
Seleção do Doador
/
Eritrócitos
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Ferritinas
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Deficiências de Ferro
/
Ferro
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
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Female
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Humans
/
Male
Idioma:
En
Revista:
Transfusion
Ano de publicação:
2018
Tipo de documento:
Article