Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance.

Salami, Jemilat; Alabi, Shanique; Willard, Ryan R; Vitale, Nick J; Wang, Jing; Dong, Hanqing; Jin, Meizhong; McDonnell, Donald P; Crew, Andrew P; Neklesa, Taavi K; Crews, Craig M

Salami, Jemilat; Alabi, Shanique; Willard, Ryan R; Vitale, Nick J; Wang, Jing; Dong, Hanqing; Jin, Meizhong; McDonnell, Donald P; Crew, Andrew P; Neklesa, Taavi K; Crews, Craig M.

Afiliação

Salami J; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, 06511, CT, USA.
Alabi S; Department of Pharmacology, Yale School of Medicine, New Haven, 06510, CT, USA.
Willard RR; Arvinas, LLC, 5 Science Park, New Haven, 06511, CT, USA.
Vitale NJ; Arvinas, LLC, 5 Science Park, New Haven, 06511, CT, USA.
Wang J; Arvinas, LLC, 5 Science Park, New Haven, 06511, CT, USA.
Dong H; Arvinas, LLC, 5 Science Park, New Haven, 06511, CT, USA.
Jin M; Arvinas, LLC, 5 Science Park, New Haven, 06511, CT, USA.
McDonnell DP; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, 27710, NC, USA.
Crew AP; Arvinas, LLC, 5 Science Park, New Haven, 06511, CT, USA.
Neklesa TK; Arvinas, LLC, 5 Science Park, New Haven, 06511, CT, USA.
Crews CM; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, 06511, CT, USA. craig.crews@yale.edu.

Commun Biol ; 1: 100, 2018.

Article em En | MEDLINE | ID: mdl-30271980

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Commun Biol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

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