Protein-protein interactions in trans-AT polyketide synthases.
Nat Prod Rep
; 35(10): 1097-1109, 2018 10 17.
Article
em En
| MEDLINE
| ID: mdl-30280735
ABSTRACT
Covering up to 2018 The construction of polyketide natural products by type I modular polyketide synthases (PKSs) requires the coordinated action of several protein subunits to ensure biosynthetic fidelity. This is particularly the case for trans-AT PKSs, which in contrast to most cis-AT PKSs, contain split modules and employ several trans-acting catalytic domains. This article summarises recent advances in understanding the protein-protein interactions underpinning subunit assembly and intra-subunit communication in such systems and highlights potential avenues and approaches for future research.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Policetídeo Sintases
/
Domínios e Motivos de Interação entre Proteínas
Idioma:
En
Revista:
Nat Prod Rep
Assunto da revista:
QUIMICA
Ano de publicação:
2018
Tipo de documento:
Article