miR-191 modulates B-cell development and targets transcription factors E2A, Foxp1, and Egr1.
Eur J Immunol
; 49(1): 121-132, 2019 01.
Article
em En
| MEDLINE
| ID: mdl-30281154
ABSTRACT
The interdependence of posttranscriptional gene regulation via miRNA and transcriptional regulatory networks in lymphocyte development is poorly understood. Here, we identified miR-191 as direct upstream modulator of a transcriptional module comprising the transcription factors Foxp1, E2A, and Egr1. Deletion as well as ectopic expression of miR-191 resulted in developmental arrest in B lineage cells, indicating that fine tuning of the combined expression levels of Foxp1, E2A, and Egr1, which in turn control somatic recombination and cytokine-driven expansion, constitutes a prerequisite for efficient B-cell development. In conclusion, we propose that miR-191 acts as a rheostat in B-cell development by fine tuning a key transcriptional program.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
/
Linfócitos B
/
MicroRNAs
/
Fatores de Transcrição Hélice-Alça-Hélice Básicos
/
Proteína 1 de Resposta de Crescimento Precoce
/
Fatores de Transcrição Forkhead
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Eur J Immunol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Alemanha