An amplification unit in human melanoma cells showing partial homology with sequences of human papillomavirus type 9 and with nuclear antigen 1 of the Epstein-Barr virus.
Cancer Res
; 47(16): 4485-92, 1987 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-3038312
ABSTRACT
By partial homology with the DNA of human papillomavirus type 9 a cellular amplification unit was detected which is amplified in melanoma cells but not in Epstein-Barr virus-transformed B cells of two melanoma patients. A 2.4-kilobase EcoRI fragment of this amplification unit was cloned and designated mel/HPV9. At the chromosomal level we detected mel/HPV9 in homogeneously staining regions or in abnormally banded regions containing different marker chromosomes of both melanoma cell lines. DNA sequence analysis of a part of mel/HPV 9 revealed homology with the third internal repeat array of Epstein-Barr virus nuclear antigen 1.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Papillomaviridae
/
DNA Viral
/
Sequência de Bases
/
Homologia de Sequência do Ácido Nucleico
/
Amplificação de Genes
/
Melanoma
/
Antígenos Virais
Limite:
Humans
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
1987
Tipo de documento:
Article