Histamine-4 receptor antagonist JNJ7777120 inhibits pro-inflammatory microglia and prevents the progression of Parkinson-like pathology and behaviour in a rat model.

Zhou, Pei; Homberg, Judith R; Fang, Qiuyuan; Wang, Jiaqi; Li, Weizhuo; Meng, Xianzong; Shen, Junqing; Luan, Yi; Liao, Peng; Swaab, Dick F; Shan, Ling; Liu, Chunqing

Zhou, Pei; Homberg, Judith R; Fang, Qiuyuan; Wang, Jiaqi; Li, Weizhuo; Meng, Xianzong; Shen, Junqing; Luan, Yi; Liao, Peng; Swaab, Dick F; Shan, Ling; Liu, Chunqing.

Afiliação

Zhou P; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China; Department of Clinical Laboratory, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei 443003, China.
Homberg JR; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
Fang Q; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China.
Wang J; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China.
Li W; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China.
Meng X; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China.
Shen J; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China.
Luan Y; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China; Department of Clinical Laboratory, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Liao P; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China.
Swaab DF; Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands.
Shan L; Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands. Electronic address: l.shan@nin.knaw.nl.
Liu C; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China. Electronic address: liuchunqing@dlmedu.edu.cn.

Brain Behav Immun ; 76: 61-73, 2019 02.

Article em En | MEDLINE | ID: mdl-30408497

Assuntos

Microglia/efeitos dos fármacos; Doença de Parkinson/metabolismo; Receptores Histamínicos H4/metabolismo; Animais; Comportamento Animal/efeitos dos fármacos; Encéfalo/metabolismo; Corpo Estriado/metabolismo; Modelos Animais de Doenças; Progressão da Doença; Neurônios Dopaminérgicos/metabolismo; Histamina/metabolismo; Indóis/farmacologia; Inflamação/metabolismo; Masculino; Microglia/metabolismo; Degeneração Neural/metabolismo; Doença de Parkinson/imunologia; Doença de Parkinson/patologia; Transtornos Parkinsonianos/metabolismo; Piperazinas/farmacologia; Ratos; Ratos Sprague-Dawley; Receptores Histamínicos H4/agonistas; Rotenona/farmacologia; alfa-Sinucleína/metabolismo

Palavras-chave

Histamine 4 receptor antagonist; Microglia; Parkinson's disease; Rotenone; α-Synuclein

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Microglia / Receptores Histamínicos H4 Limite: Animals Idioma: En Revista: Brain Behav Immun Assunto da revista: ALERGIA E IMUNOLOGIA / CEREBRO / PSICOFISIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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