Mechanisms of HLA-DP Antigen Processing and Presentation Revisited.

Anczurowski, Mark; Hirano, Naoto

Anczurowski, Mark; Hirano, Naoto.

Afiliação

Anczurowski M; Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, M5G 2M9, Canada; Department of Immunology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
Hirano N; Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, M5G 2M9, Canada; Department of Immunology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. Electronic address: naoto.hirano@uhnresearch.ca.

Trends Immunol ; 39(12): 960-964, 2018 12.

Article em En | MEDLINE | ID: mdl-30416081

ABSTRACT

ABSTRACT

Polymorphisms in HLA-DP can modulate interactions with the invariant chain chaperone, contributing independently to differences in the peptide repertoire presented on DP. The resulting presentation of intracellular antigens directly to CD4+ T cells may partly explain genetic and clinical studies describing previously unexplained links between polymorphism in DP and disease.

Assuntos

Apresentação de Antígeno/imunologia; Antígenos HLA-DP/imunologia; Linfócitos T CD4-Positivos/imunologia; Antígenos HLA-DP/genética; Humanos; Peptídeos/imunologia; Polimorfismo Genético/genética; Polimorfismo Genético/imunologia

Palavras-chave

HLA Class II; HLA-DP; autoimmune disease; cancer; invariant chain; viral disease

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígenos HLA-DP / Apresentação de Antígeno Limite: Humans Idioma: En Revista: Trends Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Canadá

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