1,4,7-Triazacyclononane Restores the Activity of ß-Lactam Antibiotics against Metallo-ß-Lactamase-Producing <i>Enterobacteriaceae</i>: Exploration of Potential Metallo-ß-Lactamase Inhibitors.

Somboro, Anou M; Amoako, Daniel G; Osei Sekyere, John; Kumalo, Hezekiel M; Khan, René; Bester, Linda A; Essack, Sabiha Y

1,4,7-Triazacyclononane Restores the Activity of ß-Lactam Antibiotics against Metallo-ß-Lactamase-Producing Enterobacteriaceae: Exploration of Potential Metallo-ß-Lactamase Inhibitors.

Somboro, Anou M; Amoako, Daniel G; Osei Sekyere, John; Kumalo, Hezekiel M; Khan, René; Bester, Linda A; Essack, Sabiha Y.

Afiliação

Somboro AM; Antimicrobial Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa anou.somboro@gmail.com.
Amoako DG; Biomedical Resource Unit, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Osei Sekyere J; Antimicrobial Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Kumalo HM; Biomedical Resource Unit, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Khan R; Department of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Bester LA; Discipline of Medical Biochemistry, School of Laboratory Medicine and Medical Science, University of KwaZulu-Natal, Durban, South Africa.
Essack SY; Discipline of Medical Biochemistry, School of Laboratory Medicine and Medical Science, University of KwaZulu-Natal, Durban, South Africa.

Appl Environ Microbiol ; 85(3)2019 02 01.

Article em En | MEDLINE | ID: mdl-30478231

Assuntos

Antibacterianos/farmacologia; Enterobacteriaceae/efeitos dos fármacos; Compostos Heterocíclicos/farmacologia; Inibidores de beta-Lactamases/farmacologia; beta-Lactamases/metabolismo; beta-Lactamas/farmacologia; Enterobacteriaceae/enzimologia; Enterobacteriaceae/genética; Infecções por Enterobacteriaceae/microbiologia; Humanos; Testes de Sensibilidade Microbiana; beta-Lactamases/genética

Palavras-chave

Enterobacteriaceae; TACN; binding affinity; metallo-ß-lactamase inhibitor; ß-lactams

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Beta-Lactamases / Beta-Lactamas / Enterobacteriaceae / Inibidores de beta-Lactamases / Compostos Heterocíclicos / Antibacterianos Tipo de estudo: Guideline Limite: Humans Idioma: En Revista: Appl Environ Microbiol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: África do Sul

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google