In Vitro Study of the Modulatory Effects of Levofloxacin and BCG on Secretion of Proinflammatory Cytokines in Infiltrative Pulmonary Tuberculosis.

Serebryakova, V A; Urazova, O I; Novitsky, V V; Vengerovskii, A I; Kononova, T E

Serebryakova, V A; Urazova, O I; Novitsky, V V; Vengerovskii, A I; Kononova, T E.

Afiliação

Serebryakova VA; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia. serebryakova-val@mail.ru.
Urazova OI; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
Novitsky VV; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
Vengerovskii AI; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
Kononova TE; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.

Bull Exp Biol Med ; 166(2): 225-228, 2018 Dec.

Article em En | MEDLINE | ID: mdl-30488211

ABSTRACT

ABSTRACT

The effects levofloxacin (fluoroquinolone) and vaccinal BCG strain on cytokine production by blood mononuclear leukocytes was studied in patients with infiltrative pulmonary tuberculosis. Combined treatment with levofloxacin and vaccinal BCG strain suppressed the production of TNFα in drug-resistant pulmonary tuberculosis and production of IL-12 and IFNÎ³ in drug-sensitive tuberculosis.

Assuntos

Antibacterianos/farmacologia; Vacina BCG/farmacologia; Leucócitos Mononucleares/efeitos dos fármacos; Levofloxacino/farmacologia; Tuberculose Pulmonar/imunologia; Adulto; Estudos de Casos e Controles; Combinação de Medicamentos; Farmacorresistência Bacteriana Múltipla; Feminino; Humanos; Interferon gama/biossíntese; Interferon gama/imunologia; Interleucina-12/biossíntese; Interleucina-12/imunologia; Interleucina-2/biossíntese; Interleucina-2/imunologia; Leucócitos Mononucleares/imunologia; Leucócitos Mononucleares/microbiologia; Masculino; Pessoa de Meia-Idade; Mycobacterium bovis/citologia; Mycobacterium bovis/imunologia; Mycobacterium tuberculosis/citologia; Mycobacterium tuberculosis/imunologia; Mycobacterium tuberculosis/patogenicidade; Cultura Primária de Células; Tuberculose Pulmonar/microbiologia; Tuberculose Pulmonar/patologia; Fator de Necrose Tumoral alfa/biossíntese; Fator de Necrose Tumoral alfa/imunologia

Palavras-chave

cytokines; levofloxacin; mononuclear leukocytes; pulmonary tuberculosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose Pulmonar / Leucócitos Mononucleares / Vacina BCG / Levofloxacino / Antibacterianos Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Bull Exp Biol Med Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Federação Russa

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